1454694-90-6

Basic information

• Product Name: C₂₄H₂₄ClFN₈O
• CAS NO: 1454694-90-6
• Molecular Weight: 494.959
• Mol File: 1454694-90-6.mol

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₄ClFN₈O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₄ClFN₈O(1454694-90-6)
• EPA Substance Registry System: C₂₄H₂₄ClFN₈O(1454694-90-6)

Safety Data

• Hazardous Substances Data: 1454694-90-6(Hazardous Substances Data)

Upstream product

• 6601-22-5 2,6-Dichloro-4-morpholino-1,3,5-triazine 
• 5407-57-8 N-(7-chloroquinolin-4-yl)ethylenediamine 
• 942045-32-1 6-chloro-N-(4-fluorophenyl)-6-morpholino-1,3,5-triazin-2-amine 
• 86-98-6 4,7-dichloroquinoline 

Relevant articles and documents

Anticancer activity of 4-aminoquinoline-triazine based molecular hybrids

In this study the potential for anticancer activity of 4-aminoquinoline- triazine based hybrids has been investigated on 60 human cancer cell lines (NCI 60). The representative compounds show activity on a range of cell lines and apoptosis as the mode of growth inhibition. The Royal Society of Chemistry 2014.

4-aminoquinoline-triazine-based hybrids with improved in vitro antimalarial activity against CQ-sensitive and CQ-resistant strains of plasmodium falciparum

A systematic chemical modification in the triazine moiety covalently attached via suitable linkers to 4-amino-7-chloroquinolines yielded a series of new 7-chloro-4-aminoquinoline-triazine hybrids exhibiting high in vitro activity against W2 (chloroquine-resistant) and D6 (chloroquine-sensitive) strains of Plasmodium falciparum without any toxicity against mammalian cell lines (Vero, LLC-PK11, HepG2). Many of the compounds (6, 8, 10, 11, 13, 14, 16, 27, 29 and 33) showed excellent potency against chloroquine sensitive and resistant strains. In particular, compounds 6, 8, 14, 16 and 29 were found to be significantly more active than chloroquine against the chloroquine-resistant strains (W2 clone) of P. falciparum.