14547-81-0

Basic information

• Product Name: 4-methoxy-N-pyridin-2-ylbenzamide
• Synonyms: 4-methoxy-N-pyridin-2-ylbenzamide
• CAS NO: 14547-81-0
• Molecular Formula: C₁₃H₁₂N₂O₂
• Molecular Weight: 228.24658
• Mol File: 14547-81-0.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-methoxy-N-pyridin-2-ylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-N-pyridin-2-ylbenzamide(14547-81-0)
• EPA Substance Registry System: 4-methoxy-N-pyridin-2-ylbenzamide(14547-81-0)

Safety Data

• Hazardous Substances Data: 14547-81-0(Hazardous Substances Data)

Upstream product

• 504-29-0 2-aminopyridine 
• 696-62-8 para-iodoanisole 
• 13939-06-5 molybdenum hexacarbonyl 
• 15226-74-1 dicobalt octacarbonyl 
• 623-12-1 4-chloromethoxybenzene 
• 66107-29-7 4-methoxyphenyl triflate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 22711-21-3 4-methoxybenzil 
• 3319-15-1 rac-1-(4-methoxyphenyl)-ethanol 
• 4160-51-4 1-(4-methoxyphenyl)-1-butanone 
• 121-97-1 4-Methoxypropiophenone 
• 104-01-8 4-Methoxyphenylacetic acid 
• 3179-10-0 1-methoxy-4-(2-nitro-vinyl)-benzene 

Downstream Products

• 86843-96-1 2-(4-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridine 

Relevant articles and documents

Co2(CO)8as a Solid CO (g) Source for the Amino Carbonylation of (Hetero)aryl Halides with Highly Deactivated (Hetero)arylamines

Carbonylation of (hetero)aryl iodides/bromides with highly deactivated 2-aminopyridines using Pd-Co(CO)4 bimetallic catalysis is accomplished. The use of Co2(CO)8 as a solid CO(g) source enhanced reaction rates observed when compared to CO(g), and excellent yields highlight the versatility of the developed protocol. A wide range of electronically and sterically demanding heterocyclic amines and (hetero)aryl iodides/bromides employed for this study resulted in excellent yields of amino carbonylated products. The developed methodology was further extended to synthesize Trypanosome brucie and luciferase inhibitors.

Direct Transformation of Alkylarenes into N-(Pyridine-2-yl)amides by C(sp3)–C(sp3) Bond Cleavage

C(sp3)–H bond functionalization and C(sp3)–C(sp3) bond cleavage are very challenging transformations in chemistry. Herein, we report a mild and green methodology for the construction of N-(pyridine-2-yl)amides via tandem C(sp3)–H activation/C–C bond cleavage of alkylarenes. Various N-heterocyclic amides were directly synthesized from alkylarenes in water in moderate to good yields.

Singlet oxygen mediated dual C-C and C-N bond cleavage in visible light

A tandem cleavage of carbon-carbon and carbon-nitrogen bonds in imidazo[1,2-a]pyridines and imidazo[1,2-a]quinolines is reported in the presence of eosin Y and visible light. The ring opening occurs under ambient conditions through singlet oxygen insertio