1454797-34-2

Upstream product

• 100-46-9 benzylamine 
• 122-04-3 4-nitro-benzoyl chloride 
• 474799-89-8 ((2R,3R,4S,5S)-1-benzyl-3,4-bis(benzyloxy)-5-(benzyloxymethyl)-pyrrolidin-2-yl)methanol 
• 1454797-31-9 (2S,3S,4R,5R)-1-benzyl-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-5-(trityloxymethyl)pyrrolidine 
• 1454797-29-5 (2R,3R,4S,5R)-1,3,4-tris(benzyloxy)-6-(trityloxy)hexane-2,5-diyldimethanesulfonate 
• 1454797-27-3 (2R,3S,4R,5R)-1,3,4-tris(benzyloxy)-6-(trityloxy)hexane-2,5-diol 
• 1454797-10-4 (2R,3S,4S)-1,3,4-tris(benzyloxy)-5-oxo-6-(trityloxy)hexan-2-yl formate 

Relevant academic research and scientific papers

Synthesis of dihydroxymethyl dihydroxypyrrolidines and steviamine analogues from C-2 formyl glycals

Synthesis of dihydroxymethyl dihydroxypyrrolidines from C-2 formyl d-glycals has been described via a common dicarbonyl intermediate. The hence obtained pyrrolidines have been further utilized for the synthesis of some steviamine analogues. The newly synthesized molecules have been evaluated for glycosidase inhibition against 6 commercially available enzymes and found to be active in the micromolar range, where one of the steviamine analogues showed good and selective inhibition of β-mannosidase (Helix pomatia).