14548-56-2Relevant academic research and scientific papers
Imidazolium-supported benzotriazole: an efficient and recoverable activating reagent for amide, ester and thioester bond formation in water
Shakoor, S.M. Abdul,Choudhary, Sunita,Bajaj, Kiran,Muthyala, Manoj Kumar,Kumar, Anil,Sakhuja, Rajeev
, p. 82199 - 82207 (2015/10/12)
An efficient and recyclable imidazolium-supported benzotriazole reagent (Im-CH2-BtH) as a novel synthetic auxiliary has been synthesized and its utility as a carboxyl group activating reagent via the formation of stable imidazolium-supported acyl benzotriazoles was explored for the synthesis of amides, esters and thioesters in water under microwave conditions. The reagent was reused five times without any noticeable loss in activity. It is moisture insensitive and highly stable under thermal and aerobic conditions. The application of imidazolium-supported N-acetyl benzotriazole leads to synthesis of paracetamol on the gram scale under greener conditions in 93% yield.
Tert-butoxide-assisted amidation of esters under green conditions
Kim, Bo Ram,Lee, Hyung-Geun,Kang, Seung-Beom,Sung, Gi Hyeon,Kim, Jeum-Jong,Park, Jong Keun,Lee, Sang-Gyeong,Yoon, Yong-Jin
experimental part, p. 42 - 50 (2012/03/26)
Efficient and green amidation reactions are of great importance. In this work, we demonstrate the tert-butoxide-assisted amidation of esters with amines under ambient conditions. Aliphatic and/or aromatic esters were converted into the corresponding amides under mild conditions in good to excellent yields. It is noteworthy that the reaction is highly efficient, rapid, versatile, green and economical, and will find great practical application in organic synthesis, biochemistry, and industrial chemistry. Georg Thieme Verlag Stuttgart. New York.
Structural systematics and conformational analyses of a 3 × 3 isomer grid of nine N-(tolyl)pyridinecarboxamides and three chlorinated relatives
Mocilac, Pavle,Gallagher, John F.
body text, p. 5354 - 5366 (2012/03/10)
A 3 × 3 isomer grid of nine N-(tolyl)pyridinecarboxamides (NxxM, x = para-/meta-/ortho-) integrating crystal structure analyses, ab initio calculations (gas phase and PCM-SMD solvated in CH2Cl2, H2O) and conformational stu
Pyridinium cationic-dimer antimalarials, unlike chloroquine, act selectively between the schizont stage and the ring stage of Plasmodium falciparum
Yoshikawa, Mai,Motoshima, Kazunori,Fujimoto, Kanji,Tai, Akihiro,Kakuta, Hiroki,Sasaki, Kenji
, p. 6027 - 6033 (2008/12/22)
Malaria is a leading cause of death in developing countries, and the emergence of strains resistant to the main therapeutic agent, chloroquine, has become a serious problem. We have developed cationic-dimer type antimalarials, MAP-610 and PMAP-H10, which
Heteroacyl Azides as Acylating Agents for Aromatic or Heteroatomic Amines (1)
Stanovnik, B.,Tisler, M.,Golob, V.,Hvala, I.,Nikolic, O.
, p. 733 - 736 (2007/10/02)
The possibility of formation of substituted heterocyclic amides from heteroacyl azides and aromatic or heteroatomic amines was investigated.Although acylation proceeded in some cases under mild reaction conditions, formation of N,N'-disubstituted ureas was the main process at elevated temperatures.
