145486-63-1

Upstream product

• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 145485-04-7 3(R)-amino-1,3,4,5-tetrahydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-2H-1-benzazepin-2-one hydrochloride 
• 168074-28-0 3(R)-3-methyl-N-<2,3,4,5-tetrahydro-2-oxo-(1H)-1-benz-azepin-3-yl>-2-butenamide 
• 137036-55-6 (R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one 
• 168074-29-1 3(R)-3-methyl-N-<2,3,4,5-tetrahydro-2-oxo-1-<<<2'-(N-triphenylmethyl)-tetrazol-5-yl><1,1'-biphenyl>-4-yl>-methyl>-1H-1-benzazepin-3-yl>-2-butenamide 

Relevant academic research and scientific papers

Michael additions of 3,3-dimethylacrylamides and amines: Synthesis of the growth hormone secretagogue L-692,585

A highly efficient synthesis of the potent Human Growth Hormone Secretagogue L-692,585 1 via a Micheal addition with a 3,3-dimethyl acrylic acid derivative 7 and (R)-1-amino-2-propanol 2 is presented.

Benzo-fused lactams that promote the release of growth hormone

There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such benzo-fused lactams as the active ingredient thereof are also disclosed.