1454868-12-2Relevant academic research and scientific papers
Synthesis, cytotoxicity, antioxidant and antimicrobial activity of indole based novel small molecules
Kurt-K?z?ldo?an, Asl?han,Otur, ?i?dem,Y?lmaz, Can,Arslan, Sevki,Mutlu, Dogukan,Kivrak, Arif,Algso, Muheb,Kayhan, Abdussamet,?etin, Do?an,Konus, Metin
, p. 461 - 470 (2021/10/02)
Aims: In this study experiments were carried out to explore antioxidant, antimicrobial, cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1H-indole (EPI) together with its effect on glutathione S-transferases (GST) activities in human liver carcinoma (HepG2) cells. Background: Indoles probably represent one of the most important heterocyclic structures that have been attracting the interest of many scientists in drug discovery. Objective: The present study was carried out to explore antioxidant, antimicrobial, cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1H-indole (EPI) and its effect on glutathione S-transferases (GST) activities in human liver carcinoma (HepG2) cells. Materials and Methods: Pd-catalyst Sonogashira coupling reactions, MTT Assay, Antioxidant capacity test, Antimicrobial test, GST enzyme activity test Results: 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties. It displayed significant induction in glutathione S-transferases (GST) enzyme activity in human liver cancer cell lines (HepG2), but cytotoxic effect on all tested cancer cell lines could not be observed. Conclusion: All of these results showed that 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties without cytotoxic effect, which could make it a promising active component with further studies..
Enhanced π-frustration in carbo-benzenic chromophores
Baglai, Iaroslav,Maraval, Valerie,Bijani, Christian,Saffon-Merceron, Nathalie,Voitenko, Zoia,Volovenko, Yulian M.,Chauvin, Remi
supporting information, p. 8374 - 8376 (2013/09/23)
The synthesis, structure, and absorption spectra of highly π-frustrated carbo-benzenes with indolic enamine substituents more or less directly conjugated to the C18 macro-aromatic core are described, and their peculiar reactivity is analyzed.
