13228-39-2

Basic information

• Product Name: 1-Ethyl-2-phenylindole
• Synonyms: 1-ETHYL-2-PHENYLINDOLE;1-ETHYL-2-PHENYL-1H-INDOLE;LABOTEST-BB LT00454321;N-ETHYL-2-PHENYLINDOLE;1-ETHYL-2-PHENYL INDOLE HPLC 96.0% YELLOW CRYSTALLINE POWDER
• CAS NO: 13228-39-2
• Molecular Formula: C₁₆H₁₅N
• Molecular Weight: 221.3
• EINECS: 236-199-8
• Product Categories: Intermediates of Dyes and Pigments;Indole;Indoles;Simple Indoles;Heterocycle-Indole series;intermediates
• Mol File: 13228-39-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 85-86°C
• Boiling Point: 209 °C / 19mmHg
• Flash Point: 190 °C
• Appearance: yellow crystalline powder
• Density: 1.03 g/cm³
• Vapor Pressure: 5.91E-06mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 168581
• CAS DataBase Reference: 1-Ethyl-2-phenylindole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Ethyl-2-phenylindole(13228-39-2)
• EPA Substance Registry System: 1-Ethyl-2-phenylindole(13228-39-2)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 22-24/25
• Hazardous Substances Data: 13228-39-2(Hazardous Substances Data)

Usage

General Description

1-Ethyl-2-phenylindole is a chemical compound that belongs to the indole class of organic compounds. It is a yellow-green to dark green crystalline solid that is commonly used as a starting material for the synthesis of various pharmaceuticals, dyes, and agrochemicals. It is also utilized as a reagent in the detection of various biological compounds, such as aldehydes and ketones. Additionally, its unique chemical structure and properties make it useful in the development of new materials and research applications in the field of organic chemistry. However, it is important to handle 1-Ethyl-2-phenylindole with caution as it may pose health risks if not used and stored properly.

InChI:InChI=1/C16H15N/c1-2-17-15-11-7-6-10-14(15)12-16(17)13-8-4-3-5-9-13/h3-12H,2H2,1H3

Upstream product

• 32119-56-5 2-(ethyl(phenyl)amino)-1-phenylethan-1-one 
• 58810-36-9 1'-ethyl-2,2'-diphenyl-1,2-dihydro-1'H-[2,3']biindolyl-3-one 
• 612-64-6 N-ethyl-N-nitrosoaniline 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 98-86-2 acetophenone 
• 583-11-9 N-(1-phenylethylidene)phenylhydrazine 
• 74-96-4 ethyl bromide 
• 948-65-2 2-phenyl-indole 
• 10604-59-8 N-Ethylindole 
• 108-86-1 bromobenzene 
• 591-50-4 iodobenzene 
• 98-80-6 phenylboronic acid 
• 103-69-5 N-ethyl-N-phenylamine 
• 120-72-9 indole 

Downstream Products

• 102316-67-6 (1-ethyl-2-phenyl-indol-3-yl)-glyoxylic acid dimethylamide 
• 78395-77-4 1-ethyl-2-phenyl-3-phenylazo-indole 
• 53603-64-8 1-ethyl-3-nitroso-2-phenyl-1H-indole 
• 99708-00-6 N-ethyl-3-indolocarbocyanine chloride 
• 99707-99-0 N-ethyl-3-indolocarbocyanine perchlorate 
• 78395-76-3 1-ethyl-2-phenyl-3-(p-nitrophenylazo)indole 
• 137449-26-4 1,3-diethyl-2-phenylindole 
• 155503-10-9 2-(1'-Ethyl-2'-phenylindol-3'-yl)-1,3-dinitropropan 
• 102552-35-2 1-(1-ethyl-2-phenyl-indol-3-yl)-2-dimethylamino-ethanol 
• 348136-85-6 1-ethyl-2-phenyl-3-(pyrrolidin-1-yl-o-tolylmethyl)-1H-indole 
• 348136-87-8 1-ethyl-2-phenyl-3-(phenylpyrrolidin-1-yl-methyl)-1H-indole 
• 348136-86-7 3-[(2-chlorophenyl)-piperidin-1-yl-methyl]-1-ethyl-2-phenyl-1H-indole 
• 168832-64-2 1-(1-ethyl-2-phenylindol-3-yl)-1-phenylethylene 
• 124521-57-9 1,1-bis(1-ethyl-2-phenylindole-3-yl)-ethylene 

Relevant articles and documents

Atom Efficient Magnesiation of N-Substituted Alkyl Indoles with a Mixed Sodium-Magnesium Base

This study presents the alkali metal mediated magnesiation (AMMMg) of three N-alkylated indoles with the mixed Na/Mg base [(TMEDA)Na(TMP)2Mg(CH2SiMe3)] 1 (TMEDA = N,N,N′,N′-tetramethylethylenediamine, TMP = 2,2,6,6-tetramethylpiperidine). All three magnesiated indoles have been successfully characterised by single-crystal X-ray diffraction and solution state NMR studies, whereas iodolysis and Pd-catalysed cross coupling have been investigated. The steric nature of the N-alkyl group changes the reactivity and efficiency of 1 to give either atom efficient disodium tetraindol-2-ylmagnesiates [(Na-TMEDA)2Mg(α-C9H8N)4] 2 and [(Na-TMEDA)2Mg(α-C10H11N)4] 3, or [(TMEDA)Na(TMP)(α-C11H12N)Mg(TMP)] 4, whereby only one indole molecule is selectively deprotonated.

In Situ Preparation of Palladium Nanoparticles for C-2 Selective Arylation of Indoles in Agro-Waste Extract Based Mixed Solvents

An efficient and practical method for the in situ generation of palladium nanoparticles was successfully established in a water extract of pomelo peel ash. The produced palladium nanoparticles were characterized by energy-dispersive X-ray spectroscopy elemental mapping, field emission scanning electron microscopy, high-resolution transmission electron microscope, X-ray powder diffraction, and showed high catalytic activity for selective C-2 arylation of indoles. A series of 2-arylindoles were smoothly installed in moderate to good yields through the direct palladium-catalyzed cross-coupling reactions of indoles and iodoarenes without external ligand, base, oxidant, and preinstallation directing group.

A highly efficient and recyclable Fe3O4 magnetic nanoparticle immobilized palladium catalyst for the direct C-2 arylation of indoles with arylboronic acids

A highly efficient Fe3O4 magnetic nanoparticle (MNP) immobilized palladium catalyst was prepared and applied to the direct C-2 arylation of indoles with arylboronic acids. The reactions generated the corresponding cross-coupling products in good yields. In addition, the supported catalyst with low loading (2.0 mol%) showed high stability and could be recovered and reused 8 times without significant loss of activity. The Royal Society of Chemistry 2014.