1454903-85-5Relevant academic research and scientific papers
(4E)-4-(4-SUBSTITUTED BENZYLIDENEAMINO)-2,3-DIHYDRO-3- SUBSTITUTED-2-THIOXOTHIAZOLE-5-CARBONITRILES AS A2AR ANTAGONIST AND PROCESS FOR PREPARATION THEREOF
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Page/Page column 15; 16, (2014/07/22)
The present, invention relates to novel the (4E)-4-(4-substituted benzylideneamino)- 2,3-dihydro-3-substituted -2-thioxothiazole-5-carbonitriles of general formula A and a process for the preparation thereof. The compounds of present invention are useful in the treatment of central nervous disorders including, Parkinson disease, Huntington's disease, attention disorder, cognition, Alzheimer disease, depression and hypertension.
Design and synthesis of (4E)-4-(4-substitutedbenzylideneamino)-3- substituted-2,3-dihydro-2-thioxothiazole-5-carbonitrile as novel A2A receptor antagonists
Mishra, Chandra Bhushan,Sharma, Dimpy,Prakash, Amresh,Kumari, Namrata,Kumar, Nitin,Luthra, Pratibha Mehta
, p. 6077 - 6083 (2013/09/23)
Novel 2-thioxothiazole derivatives (6-19) as potential adenosine A 2A receptor (A2AR) antagonists were synthesized. The strong interaction of the compounds (6-19) with A2AR in docking study was confirmed by high binding af
