13251-19-9

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
4-aMino-3-phenyl-2-thioxo-2,3-dihydrothiazole-5-carbonitrile is used as a promising candidate for the development of new drugs and therapeutic agents due to its unique structure and functional groups.
Used in Antimicrobial Applications:
In the field of antimicrobial research, 4-aMino-3-phenyl-2-thioxo-2,3-dihydrothiazole-5-carbonitrile is used as an antimicrobial agent to combat various types of infections caused by bacteria and other microorganisms.
Used in Anticancer Applications:
4-aMino-3-phenyl-2-thioxo-2,3-dihydrothiazole-5-carbonitrile is used as an anticancer agent, showing potential in the treatment of various types of cancer. Its specific application reason is not provided in the materials.
Used as an Anticonvulsant:
4-aMino-3-phenyl-2-thioxo-2,3-dihydrothiazole-5-carbonitrile is used as an anticonvulsant, indicating its potential in managing conditions related to seizures and epilepsy.

InChI:InChI=1/C10H7N3S2/c11-6-8-9(12)13(10(14)15-8)7-4-2-1-3-5-7/h1-5H,12H2

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 109-77-3 malononitrile 
• 1885-22-9 bromomalononitrile 
• 1074-52-8 ammonium N-phenyldithiocarbamate 

Downstream Products

• 81402-84-8 4-Amino-2-[(E)-4-methoxy-phenylimino]-3-phenyl-2,3-dihydro-thiazole-5-carbonitrile 
• 81402-86-0 4-amino-2-hydrazino-3-phenylhydrazino-2,3-dihydrothiazole-5-carbonitrile 
• 81402-85-9 4-Amino-2-[(E)-benzylimino]-3-phenyl-2,3-dihydro-thiazole-5-carbonitrile 
• 159897-83-3 4-(ethoxymethylene)amino-3-phenlyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carbonitrile 
• 82013-39-6 4-Amino-3-phenyl-3-thioxo-Δ⁴-thiazolin-5-thiocarboxamid 
• 81402-77-9 4-amino-2-hydrazino-3-phenyl-2,3-dihydrothiazole-5-carbonitrile 
• 159897-52-6 7-amino-3-phenylthiazolo[4,5-d]pyrimidin-2(3H)-thione 
• 130089-91-7 3-Phenyl-3H,6H-thiazolo[4,5-d]pyrimidine-2,7-dithione 
• 1454903-76-4 (4E)-4-(4-fluorobenzylideneamino)-3-phenyl-2,3-dihydro-2-thioxothiazole-5-carbonitrile 
• 1454903-80-0 (E)-4-(4-chlorobenzylideneamino)-N₃-phenyl-2,3-dihydro-2-thioxothiazole-5-carbonitrile 
• 1454903-85-5 (E)-4-(4-bromobenzylideneamino)-N₃-phenyl-2,3-dihydro-2-thioxothiazole-5-carbonitrile 

Relevant academic research and scientific papers

Design and synthesis of (4E)-4-(4-substitutedbenzylideneamino)-3- substituted-2,3-dihydro-2-thioxothiazole-5-carbonitrile as novel A2A receptor antagonists

Novel 2-thioxothiazole derivatives (6-19) as potential adenosine A 2A receptor (A2AR) antagonists were synthesized. The strong interaction of the compounds (6-19) with A2AR in docking study was confirmed by high binding af

Novel 8-(furan-2-yl)-3-substituted thiazolo [5,4-e][1,2,4] triazolo[1,5-c] pyrimidine-2(3H)-thione derivatives as potential adenosine A2A receptor antagonists

Novel thiazolotriazolopyrimidine derivatives (23-33) designed as potential adenosine A2A receptor (A2AR) antagonists were synthesized. Molecular docking studies revealed that all compounds (23-33) exhibited strong interaction with A

Synthesis of novel 7-imino-2-thioxo-3,7-dihydro-2H-thiazolo [4,5-d] pyrimidine derivatives as adenosine A2A receptor antagonists

Novel bicyclic thiazolopyrimidine compounds (15-26) were synthesized to develop adenosine A2A receptor (A2AR) antagonist for the treatment of Parkinson's disease (PD). The binding affinity of the compounds (15-26) with A2A

Synthesis of some urea and thiourea derivatives of 3-phenyl/ethyl-2-thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidine and their antagonistic effects on haloperidol-induced catalepsy and oxidative stress in mice

A series of 3-phenyl/ethyl-2-thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidin-7-yl urea and thiourea derivatives were designed and synthesized. All the compounds have been evaluated for their antiparkinsonian activity in catalepsy induced by haloperidol in mice

Enaminonitrile in Heterocyclic Synthesis: Synthesis of Thiazolopyridine and Thiazolopyrimidine Derivatives

Ammonium N-phenyldithiocarbamate reacted with bromomalononitrile and α-chloroacetylacetone to afford thiazole derivatives 3a, b.Compound 3a reacted with benzylidenemalononitrile, malononitrile, phenylisothiocyanate, benzoylisothiocyanate, trichloroacetonitrile, formamide, carbon disulphide and triethylorthoformate to afford thiazolopyridine derivatives 6, 9 and thiazolopyrimidine derivatives 13, 16, 18, 19, 20 and 21.Most of the synthesized products show high fungicidal and bactericidal activities.

The Reaction of Active Methylene Reagents With Sulfur and Phenyl Isothiocyanate: Novel Synthesis of Thiazole, Thiazolopyrimidine, and 4,5'-Bithiazolyl Derivatives

The active methylene reagents 1a-i reacted with phenyl isothiocyanate and sulfur to afford the thiazole derivatives 2a-i.The reactivity of 2a and 2f towards various chemical reagents was studied.