1454909-07-9

Upstream product

• 1454907-96-0 ethyl bis(4-methoxyphenyl)phosphinate 
• 2789-89-1 1,2-bis(4-bromophenyl)acetylene 
• 20846-05-3 P,P-bis(4-methoxyphenyl)-N-phenylphosphinic amide 
• 62-53-3 aniline 

Relevant academic research and scientific papers

NOVEL PHOSPHININE OXIDE DERIVATIVE AND PREPARATION METHOD THEREOF

Provided are a novel phosphinine oxide derivative and a preparation method thereof, and more specifically, the phosphinine oxide derivative includes an oxaphosphinine oxide derivative and an azaphosphinine oxide derivative. The phosphinine oxide derivative according to the present invention may have a pharmacological activity and a physiological activity, and may be used as a basic framework of a natural product and may be used for development of new drug and synthesis of various medical supplies. In addition, according to the preparation method of the phosphinine oxide derivative according to the present invention, various phosphinine oxide derivatives with a high yield may be prepared by a simple synthesis process using an intramolecular annulation between a phosphinic derivative and an alkyne derivative in the presence of a rhodium (Rh) catalyst or a ruthenium (Ru) catalyst and an oxidant.

Rhodium-catalyzed oxidative coupling through C-H activation and annulation directed by phosphonamide and phosphinamide groups

Rhodium-catalyzed oxidative coupling reactions via C-H activation and annulation directed by phosphonamide and phosphinamide groups were developed under aerobic conditions, which produced benzazaphosphole 1-oxides and phosphaisoquinolin-1-oxides.