1454918-41-2

Basic information

• Product Name: C₂₀H₁₆N₄O₂
• Synonyms: C₂₀H₁₆N₄O₂
• CAS NO: 1454918-41-2
• Molecular Weight: 344.373
• Mol File: 1454918-41-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₆N₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₆N₄O₂(1454918-41-2)
• EPA Substance Registry System: C₂₀H₁₆N₄O₂(1454918-41-2)

Safety Data

• Hazardous Substances Data: 1454918-41-2(Hazardous Substances Data)

Upstream product

• 123-30-8 4-amino-phenol 
• 14254-57-0 4-(chlorocarbonyl)pyridine 
• 68280-18-2 N-(4-hydroxyphenyl)pyridine-4-carboxamide 
• 57892-76-9 2-chloromethylimidazo[1,2-a]pyridine 

Downstream Products

• 1454918-36-5 C₂₁H₁₈N₄O₂ 

Relevant articles and documents

N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors

PDE10A is a recently identified phosphodiesterase with a quite remarkable localization since the protein is abundant only in brain tissue. Based on this unique localization, research has focused extensively on using PDE10A modulators as a novel therapeutic approach for dysfunction in the basal ganglia circuit including Parkinson's disease, Huntington's disease, schizophrenia, addiction and obsessive compulsive disorder. Medicinal chemistry efforts identified the N-methyl-N-[4-(quinolin-2-ylmethoxy)-phenyl]-isonicotinamide (8) as a nanomolar PDE10A inhibitor. A subsequent Lead-optimization program identified analogous N-methylanilides and their corresponding N-methylbenzamides (29) as potent PDE10A inhibitors, concurrently some interesting and unexpected binding modes were identified.