1455028-46-2Relevant articles and documents
Stereoselective Synthesis of (Sulfonimidoyl)cyclopropanes with (R)-PhSO(NTs)CH2Cl and α,β-Unsaturated Weinreb Amides: Tuning the of Selectivity between C-Cl and C-S Bond Cleavage
Shen, Xiao,Liu, Qinghe,Zhang, Wei,Hu, Jinbo
supporting information, p. 906 - 909 (2016/03/01)
(Sulfonimidoyl)cyclopropanes have become the subject of special interest since they combine the advantages of two chemical leads (cyclopropane and sulfoximine). However, their synthesis is limited, and the stereoselective synthesis of optically enriched (sulfonimidoyl)cyclopropanes still remains an unsolved task. Here we report the first stereoselective (sulfonimidoyl)cyclopropanation reaction using α,β-unsaturated Weinreb amides and (R)-PhSO(NTs)CH2Cl [(R)-1]. This reaction possesses a broad substrate scope, and the products can be easily transformed into other useful cyclopropyl-containing and/or sulfonimidoyl-containing compounds. The Weinreb amide group and the counter cation of the base were found to be important for the selective C-Cl bond cleavage. The first (sulfonimidoyl)cyclopropanation of α,β-unsaturated carbonyl compounds with (R)-PhSO(NTs)CH2Cl was achieved to afford optically enriched (sulfonimidoyl)cyclopropanes in good yields with excellent diastereoselectivities. The reaction shows a broad substrate scope. The Weinreb amide group and the counter cation of the base were found to be important for the selective C-Cl bond cleavage.
Positive Allosteric Modulators of MGLUR2
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, (2013/09/26)
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be useful for the treatment of various disorders of the centr
