145510-84-5

Basic information

• Product Name: [2-(4-bromophenyl)-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrol-3-yl]acetic acid
• Synonyms: [4-Anilino-2-(4-bromophenyl)-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrol-3-yl]acetic acid; 1H-pyrrole-3-acetic acid, 2-(4-bromophenyl)-2,5-dihydro-5-oxo-1-phenyl-4-(phenylamino)-
• CAS NO: 145510-84-5
• Molecular Formula: C₂₄H₁₉BrN₂O₃
• Molecular Weight: 463.3233
• Mol File: 145510-84-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 632.3°C at 760 mmHg
• Flash Point: 336.2°C
• Density: 1.507g/cm³
• Vapor Pressure: 7.37E-17mmHg at 25°C
• Refractive Index: 1.697
• PKA: 4.43±0.10(Predicted)
• CAS DataBase Reference: [2-(4-bromophenyl)-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrol-3-yl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-bromophenyl)-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrol-3-yl]acetic acid(145510-84-5)
• EPA Substance Registry System: [2-(4-bromophenyl)-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrol-3-yl]acetic acid(145510-84-5)

Safety Data

• Hazardous Substances Data: 145510-84-5(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 145510-85-6 1-phenyl-5-(p-bromophenyl)-3-hydroxy-4-carboxymethyl-2,5-dihydro-2-pyrrolone 
• 328-50-7 α-ketoglutaric acid 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 145510-85-6 1-phenyl-5-(p-bromophenyl)-3-hydroxy-4-carboxymethyl-2,5-dihydro-2-pyrrolone 

Relevant articles and documents

Synthesis and biological activity of 1,5-diaryl-3-alkylamino-4-carboxymethyl-2,5-dihydropyrrol-2-ones and 1,5-diaryl-4-carboxymethyl-tetrahydropyrrol-2,3-diones

By interaction of α-ketoglutaric acid with Schiff bases 1,5-diaryl-3-arylamino-4-carboxymethyl-2,5-dihydropyrrol-2-ones 1 were obtained. Hydrolysis of the latter, carried out with hydrochlorid acid gave 1,5-diaryl-3-hydroxy-4-carboxymethyl-2,5-dihydropyrrol-2-ones 2. On treatment of 2 with aryl-amines the starting compounds 1 were yielded. All compounds were tested for their antiphlogistic activity.

FORMATION OF 1,5-DIARYL-3-ARYLAMINO-4-CARBOXY-METHYL-2,5-DIHYDROPYRROL-2-ONES BY REACTION BETWEEN 2-KETOGLUTARIC ACID AND SCHIFF BASES

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