145588-13-2

Upstream product

• 66373-95-3 4-bromo-1,2-phenylene diacetate 
• 88623-81-8 3,4-diacetoxycinnamic acid 
• 155787-74-9 5-(3,4-diacetoxyphenyl)-2(3H)-furanone 
• 5333-34-6 3-(3,4-dimethoxybenzoyl)propionic acid 
• 57596-02-8 3-(3,4-dihydroxybenzoyl)propionic acid 
• 155787-75-0 (E)-4-(4-(3,4-diacetoxybenzylidene)-5-oxo-4,5-dihydrofuran-2-yl)-1,2-phenylene diacetate 
• 26976-84-1 5-(3,4-dimethoxyphenyl)-2(3H)-furanone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Relevant academic research and scientific papers

Stereoselective synthesis of: E -3-(arylmethylidene)-5-(alkyl/aryl)-2(3 H)-furanones by sequential hydroacyloxylation-Mizoroki-Heck reactions of iodoalkynes

A modular, stereoselective synthesis of E-3-(arylidene)-5-(alkyl/aryl)-2(3H)-furanones was developed. The methodology features regioselective addition of β-aryl acrylic acids to iodoacetylenes to furnish the Z-acyloxy iodoalkenes. A stereoselective 5-exo-trig Mizoroki-Heck reaction of the acyloxy iodoalkenes generates the target E-2(3H)-furanones. The approach was applied in a formal synthesis of the naturally occurring kinase inhibitor BE-23372M.

BE-23372M, a novel protein tyrosine kinase inhibitor. III. Synthesis

In a preceding paper, the physico-chemical properties and structural elucidation of BE-23372M, a potent novel protein tyrosine kinase inhibitor, were described. In this paper, we report the synthesis of BE-23372M from 3-(3,4-dimethoxybenzoyl)propionic aci