145590-05-2Relevant academic research and scientific papers
Visible-Light-Promoted Redox-Neutral Cyclopropanation Reactions of α-Substituted Vinylphosphonates and Other Michael Acceptors with Chloromethyl Silicate as Methylene Transfer Reagent
Guo, Ting,Zhang, Li,Liu, Xiaobo,Fang, Yewen,Jin, Xiaoping,Yang, Yi,Li, Yan,Chen, Bin,Ouyang, Minghui
, p. 4459 - 4463 (2018)
The alkene cyclopropanation with chloromethyl silicate as a methylene transfer reagent has been accomplished via visible-light-mediated redox-neutral catalysis. This method features broad functional group tolerance and mild conditions. In addition to α-substituted vinylphosphonates, a range of Michael acceptors including α,β-unsaturated acrylate, ketone, amide and sulfone are suitable substrates for this photocatalytic cyclopropanation. An application of this protocol to the cyclopropanation of estrone derivative is also presented. (Figure presented.).
PERIPHERALLY SELECTIVE PIPERIDINE CARBOXYLATE OPIOID ANTAGONISTS
-
, (2008/06/13)
3,4,4-trisubstitutedpiperidinyl-N-alkylcarboxylates and intermediates for their preparation are provided. These piperidine-N-alkylcarboxylates are useful as peripheral opioid antagonists.
