145593-91-5

Upstream product

• 75800-77-0 3-deoxy-β-D-glucose 
• 98-88-4 benzoyl chloride 
• 36204-29-2 3-deoxy-D-ribo-hexopyranose 

Downstream Products

• 145593-93-7 N⁹-(3'-Deoxy-β-D-glucopyranosyl)guanin 
• 145593-92-6 N⁹-(2',4',6'-Tri-O-benzoyl-3'-deoxy-β-D-glucopyranosyl)guanin 
• 145610-61-3 N⁷-(2',4',6'-Tri-O-benzoyl-3'-deoxy-β-D-glucopyranosyl)guanin 
• 172473-67-5 2,4,6-Tri-O-benzoyl-3-deoxy-α-D-ribo-hexopyranosyl bromide 
• 145593-90-4 9-(2',3'-Dideoxy-6'-O-<(4,4'-dimethoxytriphenyl)methyl>-β-D-glucopyranosyl)-N²-isobutyrylguanin 
• 145610-81-7 Succinic acid mono-[(2R,3S,6R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-6-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-pyran-3-yl] ester 
• 145594-09-8 9-<4'-O-<(2-Cyanoethoxy)(diisopropylamino)phosphino>-2',3'-dideoxy-6'-O-<(4,4'-dimethoxytriphenyl)methyl>-β-D-glucopyranosyl>-N²-isobutyrylguanin 
• 145594-11-2 9-<2',3'-Dideoxy-6'-O-<(4,4'-dimethoxytriphenyl)methyl>-4'-O-<4-O-(4-nitrophenyl)succinyl>-β-D-glucopyranosyl>-N²-isobutyrylguanin 

Relevant academic research and scientific papers

3-deoxy oligosaccharides and pharmaceutical compositions containing them

The invention relates to 3-deoxy oligosaccharides of formula I: STR1 in which X represents an --OSO3- radical, a radical of formula R--O, a radical of formula: STR2 or a radical of formula: STR3 Y represents a radical of formula: STR4 R represents an alkyl radical, R1, R3, R5, R7, R8, R10, R12 and R13 represent a hydroxyl radical, an alkoxy radical or an --OSO3- radical, R2, R4, R6, R9 and R11 represent a hydrogen atom, a hydroxyl radical, an alkoxy radical or an --OSO3- radical, with the proviso that at least R2 or R4 or R6 or R9 or R11 represents a hydrogen atom, and their pharmaceutically acceptable salts with a base.

Syntheses of Thymidine Diphosphoglucose Derivatives

Per-O-benzoylated 3- and 4-deoxy-α-D-glucopyranoses 3 and 12, as well as the respective 4-isobutyramido derivative 29 were converted into their hemiacetals, phosphitylated, and oxidizes to yield anomeric mixtures of glycosyl phosphates.These partially esterified compounds were coupled with dTMP morpholidate to give after complete deblocking dTDP-3-deoxy-α-D-glucose (11), dTDP-4-deoxy-α-D-glucose (19) and dTDP-4-amino-4-deoxy-α-D-glucose (36). 3-Acetamido-3-deoxy-α-D-glucopyranosyl phosphate was synthesized according to the silver diphenyl phosphate procedure and subsequently converted into dTDP-3-acetamido-3-deoxy-α-D-glucose (dTDP-N-acetyl-D-kanosamine) (26) by hydrogenation and coupling with dTMP morpholidate.- Keywords: Glycosyl phosphate / Morpholidate procedure / Deoxy sugars / Nucleoside diphosphates

110. Warum Pentose- und nicht Hexose-Nucleinsaeuren? (Teil II) Oligonucleotide aus 2',3'-Dideoxy-β-D-glucopyranosyl-Bausteinen ('Homo-DNS'): Herstellung - Why Pentose and Not Hexose Nucleic Acids? Part II. Preparation of Oligonucleotides Containing 2',3'-

This paper describes the preparation of the 2',3'-dideoxy-β-D-glucopyranosyl-(= 2',3'-dideoxy-β-D-erythro-hexapyranosyl)-derived nucleosides of the five bases adenine, cytosine, guanine, thymine, and uracil (= 'homo-deoxyribonucleosides') as well as the s