1456-54-8

Upstream product

• 138234-54-5 5-Hydroxy-8-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6,7-dicarboxylic acid bis-((S)-methoxycarbonyl-phenyl-methyl) ester 
• 79289-93-3 epipodophyllic acid 4,11-acetonide 
• 112026-14-9 C₂₉H₂₈O₈ 
• 75101-88-1 methyl 1,4-epoxy-3-exo-(hydroxymethyl)-6,7-(methylenedioxy)-1-(1,2-cis)-(3',4',5'-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-2-endo-carboxylate 
• 75404-00-1 (5S,6R)-8-Oxo-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid ethyl ester 
• 75404-00-1 ethyl rel-(3R,4R)-6,7-methylenedioxy-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-3-carboxylate 
• 112026-13-8 (5S,6S,7S)-7-Benzyloxymethyl-8-oxo-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid ethyl ester 
• 112026-12-7 (5S,6S)-5-(3,4,5-Trimethoxy-phenyl)-8-trimethylsilanyloxy-5,6-dihydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid ethyl ester 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 74879-22-4 6-bromobenzo-1,3-dioxole-5-carboxaldehyde dimethyl acetal 
• 120-57-0 piperonal 
• 75101-88-1 C₂₃H₂₄O₉ 
• 1256-91-3 (+/-)-methyl epipodophyllate 
• 79305-58-1 methyl epipodophyllate 4,11-acetonide 

Downstream Products

• 77519-37-0 9-hydroxy-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 

Relevant academic research and scientific papers

A new and efficient strategy for the synthesis of podophyllotoxin and its analogues

Figure presented An efficient and stereoselective strategy for the total synthesis of podophyllotoxin was developed. This route leads to podophyllotoxin 1 in only 12 steps with 29% overall yield. A notable feature of this synthetic strategy is the use of

Asymmetric Synthesis of (-)-Neopodophyllotoxin

A five-step asymmetric synthesis of neopodophyllotoxin in 18percent overall yield and optical purity >97percent, starting from 6-(3,4,5-trimethoxybenzyl)piperonal (6) and the fumarate of (S)-methyl mandelate (8), is described.

Comprehensive Synthetic Route to Eight Diastereomeric Podophyllum Lignans

An oxabicyclo compound, 9, prepared in 47percent yield through an isobenzofuran intermediate was converted with excellent regio- and stereocontrol to eight (+/-)-lignan lactones of the podophyllotoxin series.One of the eight, epiisopicropodophyllin, 36, t

TOTAL SYNTHESIS OF (+/-) PODOPHYLLOTOXIN

A straightforward approach to podophyllotoxin was developed using silyl enol ether 5.