145618-69-5Relevant academic research and scientific papers
Substituent Effects on 1,3-Dipolar Cycloadditions to Some 1,1-Diphenyl-2-Aza-1,3-Butadiene Derivatives.
Balsamini, Cesarino,Bedini, Annalida,Spadoni, Gilberto,Burdisso, Marina,Capelli, Anna Maria
, p. 3773 - 3784 (1994)
The reactivity and in particular the siteselectivity of electrocyclic additions to 1,1-diphenyl-2-aza-1,3-butadienes, substituted or not on the terminal carbon with methyl and phenyl, and with a 3-carbomethoxyl group, have been investigated with the
New efficient synthesis of 1-aminocyclopropanecarboxylic acid (ACC)
Cativiela,Diaz-de-Villegas,Jimenez
, p. 2955 - 2963 (1992)
A new efficient synthesis of 1-aminocyclopropanecarboxylic acid (ACC) from methyl 2-diphenylmethyleneaminoacrylate in nearly quantitatie yield has been deeloped. The key step in the synthesis is the remoal of both protecting groups in mild conditions and
New α,β-Didehydroamino Acid Derivatives as Precursors in the Synthesis of 1-Aminocyclopropanecarboxylic Acids
Cativiela, Carlos,Diaz-de-Villegas, Maria D.,Jimenez, Ana I.
, p. 9157 - 9166 (2007/10/02)
The reaction of N-(diphenylmethylene)didehydroalanine methyl ester and N-didehydroalanine methyl ester with diazoalkanes or ylides gives the corresponding cyclopropane derivatives in high yields.The cis/trans ratio of these compounds was dependent on substrate, reagent and reaction temperature.From stereochemically homogeneous compounds the corresponding 1-aminocyclopropanecarboxylic acids were easily obtained by acid hydrolysis.
1-Aminocyclopropane-1-carboxylic acid derivatives: A new, general synthesis and NMDA receptor complex binding affinity study
Spadoni,Balsamini,Bedini,Mugnaini
, p. 1663 - 1674 (2007/10/02)
A new synthesis of 1-aminocyclopropane-1-carboxylic acid and of its (E)- and (Z)-2-substituted analogues (R = CH3;i-Pr;C6H5) has been performed by means of the 'diazo-addition' method, starting from N-(diphenylmethylene)-2,3-dehydro-1-amino-1-carboxylate precursors. The (E)- and (Z)-2-phenyl and the (Z)-2-methylcyclopropaneamino acids have been obtained with high diastereospecificity. All the cyclopropaneamino acids prepared were tested for their affinity for some glutamate receptors and resulted inactive, wich the exception of compounds (E)-1b and (Z)-1c which showed a shallow displacement of [H]-glycine binding.
