145628-71-3

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 39222-69-0 3-[(2-aminophenyl)amino]-5,5-dimethylcyclohex-2-en-1-one 
• 7560-72-7 2,2′?(3?nitrophenylmethylene)bis(3?hydroxy?5,5′?dimethyl?2?cyclohexen?1?one) 
• 95-54-5 1,2-diamino-benzene 
• 126-81-8 dimedone 
• 3471-13-4 dimedone 
• 140429-24-9 N-[chloro(3-nitrophenyl)methyl]pyridinium chloride 

Relevant academic research and scientific papers

Investigation of the products of interaction of cyclic diketones with nitrogen-containing 1,4-binucleophiles

The interaction of arylbis(5,5-dimethylcyclohexane-1,3-dion-2-yl)methanes with o-phenylenediamine and o-aminophenol leads to the preparation of 3,3-dimethyl-11-aryl-2,3,4,5,10,11-hexahydrobenzo[b,e]-1,4-diazepin-1-ones and 3,3,6,6-tetramethyl-9-aryl-10-(2

Synthesis and characterization of CoFe2O4@SiO2@NH-NH2-PCuW as an acidic nano catalyst for the synthesis of 1,4-benzodiazepines and a powerful dye remover

A novel magnetic heterogeneous nanocatalyst CoFe2O4@SiO2@NH-NH2-PCuW was synthesized and characterized. This powerful catalyst possesses Br?nsted and Lewis acid properties. The presence of Cu enhances the acidity of this catalyst because of the increase in the electron deficiency of polyoxometalate. It was successfully applied for the easy and efficient one-pot synthesis of 1,4-benzodiazepine derivatives directly from dimedone, o-phenylenediamine, and an aromatic aldehyde under a solvent-free condition at 80 °C. High yields in short reaction times, easy work-up, and environmental friendliness are some of the advantages of this protocol. Also, this nanocatalyst could conveniently be recovered by a magnetic field and reused several times without a significant loss of catalytic efficiency. The synthesized nanocatalyst CoFe2O4@SiO2@NH-NH2-PCuW also proved to be an excellent adsorbent for dye removal. These properties are related to the high surface area because of the nanostructure and high acidity due to the presence of Cu in polyoxometalate. Moreover, magnetic properties help better recovering of this adsorbent for dye removed from wastewater.

Design, preparation and characterization of Cu/GA/Fe3O4@SiO2 nanoparticles as a catalyst for the synthesis of benzodiazepines and imidazoles

The synthesis and characterization of an efficient and reusable nanocatalyst, Cu/GA/Fe3O4@SiO2, obtained by ultrasonic-assisted grafting of guanidineacetic acid on modified Fe3O4@SiO2 core-shell nanocomposite spheres and subsequent immobilization of Cu(II), are described. The catalyst was characterized by means of X-ray diffraction, scanning and transmission electron microscopies, energy-dispersive X-ray spectroscopy, elemental analysis, thermogravimetric analysis, Fourier transform infrared spectroscopy, vibrating sample magnetometry and inductively coupled plasma optical emission spectrometry. The prepared nanocatalyst facilitated an efficient and straightforward friendly procedure for the synthesis of benzodiazepines and imidazoles in ethanol and under solvent-free conditions, respectively. The nanocatalyst can be easily recovered using a magnet and reused several times without any significant loss of activity.

Facile three-component preparation of benzodiazepine derivatives catalyzed by zinc sulfide nanoparticles via grinding method

Abstract: In this research, ZnS nanoparticles were prepared and applied as heterogeneous reusable catalyst for synthesis of 1,5-benzodiazepines under grinding conditions at 70?°C. The multi-component reactions of aldehydes, dimedone and o-phenylenediamine

A nickel nanoparticle engineered CoFe2O4@GO-Kryptofix 22 composite: A green and retrievable catalytic system for the synthesis of 1,4-benzodiazepines in water

A composite of Ni nanoparticles incorporated in Kryptofix 22 conjugated magnetic nano-graphene oxide, CoFe2O4@GO-K 22·Ni, was synthesized via the grafting of Kryptofix 22 moieties on the magnetic nano-graphene oxide surface, followed by reaction of the nanocomposite with nickel nitrate. The Kryptofix 22 host material unit cavities can stabilize the Ni nanoparticles effectively and prevent their aggregation and separation from the surface. Characterization of the catalysts by FT-IR, FE-SEM, TGA, ICP, EDX, XRD, VSM and BET aided understanding the catalyst structure and morphology. This catalyst was efficiently applied for the synthesis of 1,4-benzodiazepine derivatives. The main advantages of the method are mild reaction conditions, inexpensive catalyst, it is environmentally benign, has high to excellent yields and shorter reaction times. This organometallic catalyst can be easily separated from a reaction mixture and was successfully examined for six runs with a slight loss of catalytic activity.

Synthesis, characterization, and molecular docking of benzodiazepines in the presence of SrFe12O19 magnetic nanocatalyst

Abstract: An efficient and concise method for the synthesis of 1,5-benzodiazepine derivatives was developed using o-phenylenediamine derivatives, 4,4-dimethyl cyclohexane-1,3-dione, and different aldehydes through a rapid three-component domino reaction i

A novel magnetic nanocatalyst Fe3O4@TiO2-H5IO6 for the green synthesis of 4-substituted-1,5-benzodiazepine derivatives

In this study, periodic acid-functionalized magnetic support (Fe3O4@TiO2-H5IO6) as a new, benign and recyclable nanocatalyst was prepared by anchoring / periodic acid onto TiO2-coated nano-Fe3O4. This catalyst was applied to achieve a high-efficiency, low-cost and eco-friendly approach for synthesizing 4-substituted-1,5-benzodiazepines with the multicomponent reactions of aromatic aldehydes, o-phenylenediamine, and dimedone. The / periodic acid group on Fe3O4@TiO2 possesses both Lewis and Br?nsted acidity, which is responsible for the high catalyst activity. The obtained results show that the catalyst performance has been acceptable in the presented research. / The catalyst could be recovered and reused up to six times without any notable decrease in its activity.

Propylphosphonic anhydride (T3P)-mediated three-component synthesis of hexahydrodibenzo[b,e][1,4]diazepin-1-one derivatives

[Figure not available: see fulltext.] In this work, the novel approach via propylphosphonic anhydride (T3P)-promoted synthesis of 1,5-benzodiazepines from o-phenylene-diamine, 5,5-dimethylcyclohexane-1,3-dione (dimedone), and aromatic aldehydes

Graphene-mesoporous anatase TiO2 nanocomposite: A highly efficient and recyclable heterogeneous catalyst for one-pot multicomponent synthesis of benzodiazepine derivatives

The potential to bias chemical reaction pathways is a significant goal for physicists and material researchers to design revolutionary materials. Recently, two-dimensional materials have appeared as a promising candidate for exploring novel catalyst activ

Ultrasound assisted 1,4-diazabicyclo[2.2.2]octaniumdiacetate multicomponent synthesis of benzodiazepines: A novel, highly efficientand green protocol

A simple and efficient method is presented for the synthesis of benzodiazepines through the multicomponent reaction of α-phenylenediamine, various aldehydes and 5,5-dimethylcyclohexane-1,3-dione (dimedone) in the presence of the acidic bis ionic liquid 1,4-diazabicyclo[2.2.2]octanium diacetate under ultrasound irradiation. The ionic liquid used is recoverable and reusable. This procedure is simple and environmentally friendly, and offers easy work-up, mild conditions and excellent yield in a short reaction time. All of the synthesized compounds were characterized by IR, 1H NMR, mass spectrometry and elemental analysis.