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CAS

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145655-18-1

2-((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxymethyl)-6-hydroxymethyl-4-(2-nitro-phenyl)-pyridine-3,5-dicarboxylic acid 3-methyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 2-((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxymethyl)-6-hydroxymethyl-4-(2-nitro-phenyl)-pyridine-3,5-dicarboxylic acid 3-methyl ester

    Cas No: 145655-18-1

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  • 145655-18-1 Structure

  • Basic information

    1. Product Name: 2-((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxymethyl)-6-hydroxymethyl-4-(2-nitro-phenyl)-pyridine-3,5-dicarboxylic acid 3-methyl ester
    2. Synonyms: 2-((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxymethyl)-6-hydroxymethyl-4-(2-nitro-phenyl)-pyridine-3,5-dicarboxylic acid 3-methyl ester
    3. CAS NO:145655-18-1
    4. Molecular Formula:
    5. Molecular Weight: 538.422
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 145655-18-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxymethyl)-6-hydroxymethyl-4-(2-nitro-phenyl)-pyridine-3,5-dicarboxylic acid 3-methyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxymethyl)-6-hydroxymethyl-4-(2-nitro-phenyl)-pyridine-3,5-dicarboxylic acid 3-methyl ester(145655-18-1)
    11. EPA Substance Registry System: 2-((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxymethyl)-6-hydroxymethyl-4-(2-nitro-phenyl)-pyridine-3,5-dicarboxylic acid 3-methyl ester(145655-18-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 145655-18-1(Hazardous Substances Data)

145655-18-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 145655-18-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,6,5 and 5 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 145655-18:
(8*1)+(7*4)+(6*5)+(5*6)+(4*5)+(3*5)+(2*1)+(1*8)=141
141 % 10 = 1
So 145655-18-1 is a valid CAS Registry Number.

145655-18-1Upstream product

145655-18-1Downstream Products

145655-18-1Relevant articles and documents

Biotransformation of nifedipine in rat and dog

Scherling,Karl,Radtke,Ahr,Siefert

, p. 1292 - 1300 (2007/10/02)

Following oral and/or intraduodenal administration, the biotransformation of 14C-labelled nifedipine (dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-dicarboxylate, Bay a 1040, Adalat, CAS 21829-25-4) has been reinvestigated in rats and dogs (dose: 5 mg/kg body weight in both species) to complete the metabolic data. Thirteen metabolites were isolated from the perfusate and bile of the isolated perfused rat liver model. Their structures were elucidated by spectroscopic methods (FAB-MS, combined GG/MS, NMR). The analyzed samples were used for the chromatographic (HPLC) comparison with urine and bile from the in vivo studies. The metabolites identified in rat urine (oral dose) account for 47.4% of the dose administered. 82.8% (rat) and 62.8% (dog) of the dose, resp., could be attributed to known structures in urine and bile following intraduodenal administration. Based on the structures identified the following biotransformation steps occured: dehydrogenation of the 1,4-dihydropyridine system, hydroxylation of the methyl groups at 2- or 6-position followed by glucuronidation or by subsequent oxidation to the carboxylic acid, and oxidative ester cleavage.

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