1456693-87-0Relevant academic research and scientific papers
3-Hydroxyisoindolin-1-one derivates: Synthesis by palladium-catalyzed C–H activation as BRD4 inhibitors against human acute myeloid leukemia (AML) cells
Chen, Pan,Yang, Yifei,Yang, Lingyun,Tian, Jiping,Zhang, Fangqing,Zhou, Jinpei,Zhang, Huibin
, p. 119 - 125 (2019)
Bromodomain protein 4 (BRD4) is a member of the bromodomain and extra-terminal domain (BET) protein family, which plays a key role in transcriptional regulation. Recent biological and pharmacological studies have enabled linking of the BET bromodomains wi
Efficient synthesis of hydroxyl isoindolones by a Pd-mediated C-H activation/annulation reaction
Yu, Qingzhen,Zhang, Nana,Huang, Jianhui,Lu, Shaonan,Zhu, Yi,Yu, Xiaoxiao,Zhao, Kang
, p. 11184 - 11188 (2013/09/02)
Radical reaction: A convenient synthesis of hydroxyl isoindolones by a Pd-catalyzed C-H activation/annulation reaction with near "click chemistry" efficiency is presented (see scheme; TBHP=tert-butyl hydrogen peroxide). This methodology features short reaction times (10-30 min), high atom economy, wide substrate scope (22 examples), and good reaction yields (up to 93 %). Copyright
