156130-44-8

Basic information

• Product Name: AlviMopan EnantioMer
• Synonyms: ALVIMOPAN ENANTIOMER;Alvimopan Isomer (2R, 3S, 4S)Q: What is Alvimopan Isomer (2R, 3S, 4S) Q: What is the CAS Number of Alvimopan Isomer (2R, 3S, 4S)
• CAS NO: 156130-44-8
• Molecular Formula: C25H32N2O4
• Mol File: 156130-44-8.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AlviMopan EnantioMer(CAS DataBase Reference)
• NIST Chemistry Reference: AlviMopan EnantioMer(156130-44-8)
• EPA Substance Registry System: AlviMopan EnantioMer(156130-44-8)

Safety Data

• Hazardous Substances Data: 156130-44-8(Hazardous Substances Data)

Upstream product

• 145590-44-9 alvimopan 
• 149541-62-8 cis-(-)-carbonic acid ethyl 1,3-dimethyl-4-[3-(l-methylethoxy)phenyl]-4-piperidinyl ester 
• 145340-44-9 1,3-dimethyl-4-[3-(propan-2-yloxy)phenyl]-4-piperidinol 
• 4629-80-5 1,3-dimethyl-4-piperidinone 
• 145678-87-1 (-)-3(S),4(S)-dimethyl-4-(3-hydroxyphenyl)piperidine 
• 131738-73-3 3-(isopropyloxy)phenylbromide 
• 223424-24-6 (3S,4S)-4-(3-Isopropoxy-phenyl)-1,3,4-trimethyl-piperidine 
• 444904-02-3 (S)-1,2,3,6-tetrahydro-1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]pyridine 
• 149541-62-8 C₁₉H₂₉NO₄ 
• 149541-62-8 C₁₉H₂₉NO₄ 
• 170098-39-2 methyl (3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinepropanoate 

Downstream Products

• 156130-44-8 2‐((R)‐2‐benzyl‐3‐((3S,4S)‐4‐(3‐hydroxyphenyl)‐3,4‐dimethylpiperidin‐1‐yl)propanamido)acetic acid 
• 156130-44-8 2‐((S)‐2‐benzyl‐3‐((3S,4S)‐4‐(3‐hydroxyphenyl)‐3,4‐dimethylpiperidin‐1‐yl)propanamido)acetic acid 
• 156053-89-3 Entereg 
• 156130-44-8 2‐((R)‐2‐benzyl‐3‐((3R,4R)‐4‐(3‐hydroxyphenyl)‐3,4‐dimethylpiperidin‐1‐yl)propanamido)acetic acid 

Relevant articles and documents

Synthesis and characterization of all possible diastereoisomers of alvimopan

Isolation of all possible diastereomers of alvimopan 1 was found to be challenging. In order to perform cut off studies during analytical method development, it was mandatory to synthesize and characterize all the diastereomeric impurities. Here in, our efforts toward the synthesis and isolation of alvimopan (1) diastereomers are discussed.

IMPROVED PROCESS FOR THE PREPARATION OF [[2(S)-[[4(R)-(3-HYDROXYPHENYL)-3(R),4-DIMETHYL-1-PIPERIDINYL]METHYL]-1-OXO-3-PHENYLPROPYL]AMINO]ACETIC ACID DIHYDRATE

The present invention relates to an improved process for the preparation of [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic acid dihydrate, represented by the following structural formula (I).

AN IMPROVED PROCESS FOR THE PREPARATION OF [[2(S)-[[4(R)-(3-HYDROXY PHENYL)-3(R), 4-DIMETHYL-1 -PIPERIDINYL]METHYL]-1 -OXO-3-PHENYLPROPYL] AMINO]ACETIC ACID DIHYDRATE

The present invention relates to an improved process for the preparation of [[2(S)-[[4(R)- (3 -hydroxypheny l)-3 (R),4-dimethyl- 1 -piperidinyl] methyl] - 1 -oxo- 3 -phenylpropyl] amino] acetic acid dihydrate, represented by the following structural formula: