1456785-10-6

Basic information

• Product Name: 3-amino-3-(3-methylphenyl)-1-phenylprop-2-en-1-one
• Synonyms: 3-amino-3-(3-methylphenyl)-1-phenylprop-2-en-1-one
• CAS NO: 1456785-10-6
• Molecular Weight: 237.301
• Mol File: 1456785-10-6.mol

Chemical Properties

• CAS DataBase Reference: 3-amino-3-(3-methylphenyl)-1-phenylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-3-(3-methylphenyl)-1-phenylprop-2-en-1-one(1456785-10-6)
• EPA Substance Registry System: 3-amino-3-(3-methylphenyl)-1-phenylprop-2-en-1-one(1456785-10-6)

Safety Data

• Hazardous Substances Data: 1456785-10-6(Hazardous Substances Data)

Upstream product

• 61946-92-7 3-methyl-N-hydroxy-benzenecarboximidoyl chloride 
• 536-74-3 phenylacetylene 
• 766-82-5 1-ethynyl-3-methyl-benzene 
• 620-22-4 3-Methylbenzonitrile 
• 98-86-2 acetophenone 
• 611-73-4 Benzoylformic acid 

Downstream Products

• 37613-13-1 3-(3?'-methylphenyl)-5-phenyl-1H-pyrazole 

Relevant articles and documents

Asymmetric Aza-Diels-Alder Reactions of in Situ Generated β,β-Disubstituted α,β-Unsaturated N-H Ketimines Catalyzed by Chiral Phosphoric Acids

A novel asymmetric synthesis of dihydropyridinones with vicinal quaternary stereocenters has been realized by asymmetric aza-Diels-Alder reactions of 3-amido allylic alcohols with oxazolones enabled by chiral phosphoric acid catalysis. A series of aryl/alkyl- and alkyl/alkyl-disubstituted 3-amido allylic tertiary alcohols and 4-substituted oxazolones could be well tolerated in these reactions, producing dihydropyridinones with excellent diastereoselectivities and high enantioselectivities. Mechanistic study and control experiments were performed to shed light on the reaction mechanism, in which a configurationally defined β,β-disubstituted α,β-unsaturated N-H ketimine was proposed as the key intermediate.

Radical Enamination of Vinyl Azides: Direct Synthesis of N-Unprotected Enamines

An electron-withdrawing-group-generable radical-induced enamination of vinyl azides is reported, which results in a variety of β-functionalized N-unprotected enamines in a stereoselective manner. A plausible mechanism involving an unusual 1,3-H transfer of in situ generated iminyl radical intermediate was proposed on the basis of experimental results and DFT calculations.

Copper on iron promoted one-pot synthesis of β-aminoenones and 3,5-disubstituted pyrazoles

The reaction of hydroximoyl chlorides with acetylenes in the presence of a copper on iron bimetallic system leads to β-aminoenones via reductive ring opening of isoxazole intermediates. The valuable β-aminoenone building blocks can be isolated or transformed into pyrazoles with the addition of hydrazine in a straightforward one-pot procedure.