1456790-22-9Relevant academic research and scientific papers
Effectiveness of novel 5-(5-amino-1-aryl-1H-pyrazol-4-yl)-1H-tetrazole derivatives against promastigotes and amastigotes of leishmania amazonensis
Dos Santos Faióes, Viviane,Leon, Leonor L.,Canto-Cavalheiro, Marilene M.,Torres-Santos, Eduardo C.,Bernardino, Alice M.R.,Vegi, Percilene F.,Dos Santos, Maurício S.
, p. 272 - 277 (2014/03/21)
In this research, a series of substituted 5-(5-amino-1-aryl-1H-pyrazol-4- yl)-1H-tetrazoles were synthesized and evaluated for in vitro antileishmanial activity. Among the derivatives, examined compounds 3b and 3l exhibited promising activity against promastigotes and amastigotes forms of Leishmania amazonensis. The cytotoxicity of these compounds was evaluated on murine cells, giving access to the corresponding selectivity index (SI).
An unexpected formation of pyrazolopyrimidines during the attempted to obtain 5-substituted tetrazoles from carbonitriles
Faria, Jéssica Venancia,Dos Santos, Maurício Silva,Vegi, Percilene Fazolin,Borges, Julio Cesar,Bernardino, Alice M.R.
supporting information, p. 5748 - 5750 (2013/09/24)
In this Letter, we described the synthesis of new 5-(5-amino-1-aryl-1H- pyrazole-4-yl)-1H-tetrazoles 2a-c from 5-amino-1-aryl-1H-pyrazole-4- carbonitriles 1a-c as well as the unexpected 1H-pyrazolo[3,4-d]pyrimidine derivatives 6a-c from 5-amino-1-aryl-3-m
