1456794-49-2

Upstream product

• 883943-05-3 dimethyl 3,3'-(prop-2-yn-1-ylazanediyl)dipropanoate 
• 25081-39-4 methyl 3,5-dimethylbenzoate 
• 581065-95-4 tert-butyl 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoate 
• 1456794-47-0 C₁₇H₂₉ClO₆P₂ 
• 1189566-01-5 tetraethyl [5-(hydroxymethyl)-1,3-phenylene]bis(methylene)diphosphonate 
• 200809-09-2 1,3-bis(bromomethyl)-5-hydroxymethylbenzene 
• 29333-41-3 methyl 3,5-bis(bromomethyl)benzoate 

Relevant academic research and scientific papers

Efficient synthesis of small-sized phosphonated dendrons: Potential organic coatings of iron oxide nanoparticles

We report herein the synthesis of biocompatible small-sized phosphonated monomers and dendrons used as functional coatings of metal oxide nanoparticles, more specifically superparamagnetic iron oxides (SPIOs) for magnetic resonance imaging (MRI) and therapy through hyperthermia. The molecules were engineered to modulate their size, their hydrophilic and/or biocompatible character (poly(amido)amine versus oligoethyleneglycol), the number of anchoring phosphonate groups (monophosphonate versus phosphonic tweezers) and the number of peripheral functional groups for further grafting of dyes or specific vectors. Such a library of hydrophilic phosphonic acids opens new possibilities for the investigation of dendronized nanohybrids as theranostics.

A bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination

The functionalization of superparamagnetic iron oxide nanoparticles (SPION) with PEGylated PAMAM dendrons through a bisphosphonate tweezers yielded 15 and 30 nm dendritic nano-objects stable in physiological media and showing both renal and hepatobiliary