145680-03-1

Basic information

• Product Name: (3R)-tetrahydrofuran-3-yl [(1S,2S,4R)-1,4-dibenzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]carbamate
• Synonyms: (3R)-tetrahydrofuran-3-yl [(2S,3S,5R)-5-benzyl-3-hydroxy-6-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-6-oxo-1-phenylhexan-2-yl]carbamate; carbamic acid, N-[(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2-hydroxy-5-oxo-1,4-bis(phenylmethyl)pentyl]-, (3R)-tetrahydro-3-furanyl ester
• CAS NO: 145680-03-1
• Molecular Formula: C₃₃H₃₈N₂O₆
• Molecular Weight: 558.6646
• Mol File: 145680-03-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 841.8°C at 760 mmHg
• Flash Point: 462.9°C
• Density: 1.28g/cm³
• Vapor Pressure: 4.27E-30mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: (3R)-tetrahydrofuran-3-yl [(1S,2S,4R)-1,4-dibenzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-tetrahydrofuran-3-yl [(1S,2S,4R)-1,4-dibenzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]carbamate(145680-03-1)
• EPA Substance Registry System: (3R)-tetrahydrofuran-3-yl [(1S,2S,4R)-1,4-dibenzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]carbamate(145680-03-1)

Safety Data

• Hazardous Substances Data: 145680-03-1(Hazardous Substances Data)

Upstream product

• 126456-36-8 L-685434 
• 138499-08-8 1-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}oxy)-2,5-pyrrolidinedione 
• 160333-50-6 1-({[(3R)-tetrahydrofuran-3-yloxy]carbonyl}oxy)pyrrolidine-2,5-dione 

Relevant articles and documents

HIV protease inhibitors useful for the treatment of aids

Compounds of the form,ψ ψ A-G-Jψ ψ wherein A is an amine protecting group or urethane, G a dipeptide isostere and J a small terminal group are described. They are distinguished by tetrahydrofuryl or tetrahydropyranyl substituents, and the like. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.ψ