1456807-80-9 Usage
Uses
Used in Pharmaceutical Industry:
2H-1-Benzopyran-2-one, 7-hydroxy-5-Methoxy-4-Methyl-3-(4-Methyl-1-piperazinyl)is used as a pharmaceutical compound for its potential therapeutic effects. Its complex structure and functional groups may contribute to its ability to interact with biological targets, such as receptors, enzymes, or proteins, and modulate their activity. This interaction could lead to the development of new drugs for the treatment of various diseases.
Used in Medicinal Chemistry Research:
2H-1-Benzopyran-2-one, 7-hydroxy-5-Methoxy-4-Methyl-3-(4-Methyl-1-piperazinyl)is used as a starting material or a building block in the synthesis of new compounds with potential medicinal properties. Its unique structure and functional groups can be further modified or combined with other chemical entities to create novel molecules with improved pharmacological profiles, such as increased potency, selectivity, or reduced side effects.
Used in Drug Delivery Systems:
2H-1-Benzopyran-2-one, 7-hydroxy-5-Methoxy-4-Methyl-3-(4-Methyl-1-piperazinyl)can be employed in the development of drug delivery systems to improve the bioavailability, stability, and targeted delivery of therapeutic agents. Its chemical properties, such as hydrophilicity or lipophilicity, can be tailored to enhance the solubility, permeability, and release of drugs in the body, leading to more effective treatments.
Used in Chemical Synthesis:
2H-1-Benzopyran-2-one, 7-hydroxy-5-Methoxy-4-Methyl-3-(4-Methyl-1-piperazinyl)can be utilized as an intermediate or a reactant in the synthesis of other complex organic compounds. Its versatile structure and functional groups make it a valuable building block for the preparation of various chemical products, such as dyes, pigments, or specialty chemicals, in the chemical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 1456807-80-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,6,8,0 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1456807-80:
(9*1)+(8*4)+(7*5)+(6*6)+(5*8)+(4*0)+(3*7)+(2*8)+(1*0)=189
189 % 10 = 9
So 1456807-80-9 is a valid CAS Registry Number.
1456807-80-9Relevant academic research and scientific papers
Preparation of coumarin derivative thereof for the application of the major diseases in the brain
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, (2018/01/11)
The invention discloses novel coumarin compounds and pharmaceutically acceptable salts thereof, the preparation method of the compounds, pharmaceutical compositions containing the compounds, and application of the compounds to preparation of medicaments for prevention or treatment of cerebral diseases, especially prevention or treatment of diseases related to neuron damage and neuroinflammation, and prevention or treatment of Parkinson's disease, dementia, cerebral ischemia, depression and cerebral apoplexy.
Coumarin derivatives protect against ischemic brain injury in rats
Sun, Mingna,Hu, Jinfeng,Song, Xiuyun,Wu, Donghui,Kong, Linglei,Sun, Yupeng,Wang, Dongmei,Wang, Yan,Chen, Naihong,Liu, Gang
, p. 39 - 53 (2013/10/01)
Neuroprotection strategies are of great importance in the treatment of ischemic brain injury. Screening of our in-stock coumarin derivatives identified compound 1 as exhibiting neuroprotective activity. Subsequently, a structural optimization was carried out, which led to the discovery of the potent compound 20. This compound signi ficantly attenuated the damage in a cell line derived from a pheochromocytoma of the rat adrenal medulla induced by oxygen-glucose deprivation in vitro. Furthermore, compound 20 exhibited clear neuroprotection in middle cerebral artery occlusion rats by reducing infarct size and brain-water content, improving neurological function, and suppressing neuronal loss and neuropathological changes in the cortex and hippocampus. Pharmacokinetic evaluation indicated that compound 20 could penetrate the blood-brain barrier of rats.
