1456819-48-9

Basic information

• Product Name: 6-(4-hydroxy-2-methyl-phenyl)-2-(p-(methanesulfonyl)phenyl)-4,5-dihydropyridazi-3(2H)-one
• Synonyms: 6-(4-hydroxy-2-methyl-phenyl)-2-(p-(methanesulfonyl)phenyl)-4,5-dihydropyridazi-3(2H)-one
• CAS NO: 1456819-48-9
• Molecular Weight: 358.418
• Mol File: 1456819-48-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(4-hydroxy-2-methyl-phenyl)-2-(p-(methanesulfonyl)phenyl)-4,5-dihydropyridazi-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-hydroxy-2-methyl-phenyl)-2-(p-(methanesulfonyl)phenyl)-4,5-dihydropyridazi-3(2H)-one(1456819-48-9)
• EPA Substance Registry System: 6-(4-hydroxy-2-methyl-phenyl)-2-(p-(methanesulfonyl)phenyl)-4,5-dihydropyridazi-3(2H)-one(1456819-48-9)

Safety Data

• Hazardous Substances Data: 1456819-48-9(Hazardous Substances Data)

Upstream product

• 108-39-4 3-methyl-phenol 
• 319494-43-4 4-(4-hydroxy-2-methyl-phenyl)-4-oxo-butyric acid 
• 877-66-7 4-(methylsulfonyl)phenylhydrazine 

Relevant articles and documents

Synthesis, antiproliferative and anti-inflammatory activities of some novel 6-aryl-2-(p-(methanesulfonyl)phenyl)-4,5-dihydropyridazi-3(2H)-ones

Sixteen new 6-aryl-2-(p-(methanesulfonyl)phenyl)-4,5-dihydropyridazi-3(2 H)-ones (2a-p) were synthesized and tested for in vitro anticancer and in vivo anti-inflammatory activities. Eleven (2b, 2d , 2-ej and 2m-p) of the obtained compounds were screened for their antiproliferative activity towards 60 human cancer cell lines by the National Cancer Institute (USA). Compound 2f showed remarkable activity with GI50 less than 1 μM on 36 human tumor cell lines and has been referred to Biological Evaluation Committee (NCI) for advance study. Compound 2g also displayed promising antiproliferative activity against 20 different cell lines with GI50 less than 1 μM. Compounds 2k and 2n were found to have a comparable anti-inflammatory activity to that of standard drug etoricoxib in carrageenan-induced rat hind paw edema model at 5 h.