877-66-7

Basic information

• Product Name: [4-(Methylsulfonyl)phenyl]hydrazine hydrochloride
• Synonyms: 4-(METHYLSULFONYL)PHENYLHYDRAZINE;4-(METHYLSULFONYL)PHENYLHYDRAZINE HYDROCHLORIDE;4-METHYLSULPHONYLPHENYLHYDRAZINE;4-METHYLSULPHONYLPHENYLHYDRAZINE HYDROCHLORIDE;4-MethylsulfonylphenylhydrazineHCl;4-METHYLSULPHONYLPHENYLHYDRAZINE HYDROCHLORIDE 95%;Hydrazine, [4-(methylsulfonyl)phenyl]-;[p-(Methylsulfonyl)phenyl]hydrazine
• CAS NO: 877-66-7
• Molecular Formula: C₇H₁₀N₂O₂S
• Molecular Weight: 222.69
• EINECS: 212-895-7
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 877-66-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 202 °C
• Boiling Point: 418.7 °C at 760 mmHg
• Flash Point: 207 °C
• Appearance: Brown to yellow powder
• Density: 1.351 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 3.97±0.20(Predicted)
• CAS DataBase Reference: [4-(Methylsulfonyl)phenyl]hydrazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(Methylsulfonyl)phenyl]hydrazine hydrochloride(877-66-7)
• EPA Substance Registry System: [4-(Methylsulfonyl)phenyl]hydrazine hydrochloride(877-66-7)

Safety Data

• Hazard Codes: Xi
• Statements: 24/25:
• Safety Statements: 24/25
• Hazardous Substances Data: 877-66-7(Hazardous Substances Data)

Usage

General Description

[4-(Methylsulfonyl)phenyl]hydrazine hydrochloride is a chemical compound that belongs to the group of hydrazines, which are widely used in organic synthesis. It is the hydrochloride salt of [4-(Methylsulfonyl)phenyl]hydrazine, and it is commonly used as a reagent in the synthesis of pharmaceuticals and agrochemicals. [4-(Methylsulfonyl)phenyl]hydrazine hydrochloride has a molecular formula of C7H10ClN3O2S and a molecular weight of 233.69 g/mol. It is a white to off-white crystalline powder that is sparingly soluble in water but soluble in organic solvents. [4-(Methylsulfonyl)phenyl]hydrazine hydrochloride has potential applications in medicinal chemistry and drug development due to its hydrazine functionality, which can be used to form a variety of bioactive compounds.

InChI:InChI=1/C7H10N2O2S/c1-12(10,11)7-4-2-6(9-8)3-5-7/h2-5,9H,8H2,1H3

Upstream product

• 3466-32-8 4-bromoohenyl methyl sulfone 
• 455-15-2 1-(methylsufonyl)-4-fluorobenzene 
• 98-57-7 4-chlorophenyl methyl sulfone 

Downstream Products

• 77606-88-3 2-(4-Methanesulfonyl-phenyl)-1,4-dihydro-2H-thiochromeno[4,3-c]pyrazol-3-one 
• 106368-32-5 5-amino-1-<4-(methylsulfonyl)phenyl>-1H-pyrazole-4-carbonitrile 
• 76012-87-8 4-[(4-Methanesulfonyl-phenyl)-hydrazono]-6,8-dimethyl-1-oxo-isochroman-7-carboxylic acid ethyl ester 
• 91110-33-7 3-(4-Methanesulfonyl-phenyl)-5,7-dimethyl-4-oxo-3,4-dihydro-phthalazine-6-carboxylic acid ethyl ester 
• 7058-21-1 2-[4-(methylsulfonyl)phenyl]-5-methyl-2,4-dihydropyrazol-3-one 
• 436863-79-5 C₁₀H₁₀N₄O₃S₂ 
• 1001420-23-0 C₂₁H₂₂N₂O₄S 
• 280551-18-0 3-(4-Chlorophenyl)-4,5-dihydro-1-(4-methylsulfonylphenyl)-1H-indazole 
• 280551-06-6 3-(4-Fluorophenyl)-4,5-dihydro-1-(4-methylsulfonylphenyl)-1H-indazole 
• 192717-34-3 2-[2-(3,5-dimethylphenyl)-5-methanesulfonyl-1H-indol-3-yl]ethylamine 
• 131803-91-3 β-ionone 4-methylsulfonylphenylhydrazone 
• 1038408-74-0 1-(4-(methylsulfonyl)phenyl)-1H-pyrazole 
• 1095263-36-7 (1R,2R)-N-(1-cyanocyclopropyl)-2-{[8-(methylsulfonyl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]carbonyl}cyclohexanecarboxamide 
• 1456819-34-3 2-(p-(methanesulfonyl)phenyl)-6-phenyl-4,5-dihydropyridazi-3(2H)-one 

Relevant articles and documents

Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents

A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model.