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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
[4-(Methylsulfonyl)phenyl]hydrazine hydrochloride is used as a reagent in the synthesis of various pharmaceuticals and agrochemicals. Its hydrazine functionality allows for the formation of a range of bioactive compounds, contributing to the development of new drugs and agricultural products.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, [4-(Methylsulfonyl)phenyl]hydrazine hydrochloride is utilized as a key intermediate for the synthesis of potential therapeutic agents. Its ability to form diverse bioactive compounds makes it valuable in the discovery and optimization of new drugs.
Used in Drug Development:
[4-(Methylsulfonyl)phenyl]hydrazine hydrochloride plays a significant role in drug development, where its unique chemical properties can be harnessed to create novel pharmaceutical entities. Its potential applications in this area highlight its importance in advancing the field of medicinal chemistry and improving healthcare outcomes.

InChI:InChI=1/C7H10N2O2S/c1-12(10,11)7-4-2-6(9-8)3-5-7/h2-5,9H,8H2,1H3

Upstream product

• 3466-32-8 4-bromoohenyl methyl sulfone 
• 98-57-7 4-chlorophenyl methyl sulfone 
• 455-15-2 1-(methylsufonyl)-4-fluorobenzene 

Downstream Products

• 111491-29-3 4-ethoxycarbonyl-1-p-(methylsulphonyl)phenyl-3-pyrazolin-5-one 
• 105674-04-2 4-ethoxycarbonyl-2-p-(methylsulphonyl)phenyl-3-pyrazolin-5-one 
• 111491-34-0 2-<2,2-bis(ethoxycarbonyl)ethenyl>-1-p-(methylsulphonyl)phenylhydrazine 
• 7058-21-1 2-[4-(methylsulfonyl)phenyl]-5-methyl-2,4-dihydropyrazol-3-one 
• 436863-79-5 C₁₀H₁₀N₄O₃S₂ 
• 906461-55-0 2-phenylchroman-4-one [4-(methylsulfonyl)phenyl]hydrazone 
• 906461-57-2 2-(4-methoxyphenyl)chroman-4-one [4-(methylsulfonyl)phenyl]hydrazone 
• 1027078-25-6 5-Bromo-3-[(4-methylsulfonyl-phenyl)-hydrazono]-1,3-dihydro-indol-2-one 
• 280551-18-0 3-(4-Chlorophenyl)-4,5-dihydro-1-(4-methylsulfonylphenyl)-1H-indazole 
• 280551-06-6 3-(4-Fluorophenyl)-4,5-dihydro-1-(4-methylsulfonylphenyl)-1H-indazole 
• 131803-91-3 β-ionone 4-methylsulfonylphenylhydrazone 
• 1046451-54-0 4,5-dihydro-6-methyl-2-(p-methylsulfonylphenyl)-3(2H)-pyridazinone 
• 1033725-90-4 3-methyl-1-(4-(methylsulfonyl)phenyl)-4,5-dihydropyrazole 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents

A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model.

New COX-2/5-LOX inhibitors: Apoptosis-inducing agents potentially useful in prostate cancer chemotherapy

The arachidonic acid metabolizing enzymes cyclooxygenase-2 (COX-2) and lipoxygenases (LOXs) have been found to be implicated in a variety of cancers, including prostate cancer. To develop new therapeutic treatments, it therefore seemed interesting to design dual COX-2/5-LOX inhibitors. We report here the synthesis and in vitro pharmacological properties of diarylpyrazole derivatives that have in their structure key pharmacophoric elements to obtain optimal interaction with subsites of active pockets in both enzyme systems. Using a molecular modeling approach, a set of SAR data is proposed, highlighting the importance of the sulfonyl group of one of the aryl moieties in terms of proliferation inhibition and/or apoptosis induction.