145695-72-3

Upstream product

• 93-97-0 benzoic acid anhydride 
• 145695-70-1 N-(2,2'-dimethylpropylidene)-N_im-trityl-L-histidine-N'-methylamide 
• 32946-56-8 N_im-trityl-L-histidine methyl ester dihydrochloride 
• 145695-69-8 N_im-trityl-L-histidine N'-methylamide 
• 630-19-3 pivalaldehyde 

Downstream Products

• 145695-77-8 (2R,4S)-3-benzoyl-2-(1,1-dimethylethyl)-4-(chloromethyl)-4-(4'-imidazolylmethyl)-1-methyl-1,3-imidazolidin-5-one 
• 145695-74-5 (2R,4S)-3-benzoyl-2-(1,1-dimethylethyl)-4-(fluoromethyl)-4-(4'-imidazolylmethyl)-1-methyl-1,3-imidazolidin-5-one 
• 145695-76-7 (2R,4S)-3-benzoyl-2-(1,1-dimethylethyl)-4-(chloromethyl)-4<(N_im-tritylimidazol-4'-yl)methyl>-1-methyl-1,3-imidazolidin-5-one 
• 145695-73-4 (2R,4S)-3-benzoyl-2-(1,1-dimethylethyl)-4-(fluoromethyl)-4-<(N_im-tritylimidazol-4'-yl)methyl>-1-methyl-1,3-imidazolidin-5-one 

Relevant academic research and scientific papers

A Novel Stereoselective Route to (S)-(+)-α-(Fluoromethyl)histidine: α-Halomethylation of (2R,4S)-3-Benzoyl-2-(1,1-dimethylethyl)-1-methyl-4--1,3-imidazolidin-5-one. Synthesis and 1H NMR Spectroscopy

A method is described for the α-enantioretentive methylation of L-histidine (S) to give (S)-(+)-α-(fluoromethyl)histidine (8).The synthesis involves the conversion of Nim-trityl-L-histidine methyl ester (1) to both the "trans"-(2S,4S)- and "cis