14573-23-0

Basic information

• Product Name: 2,6-DICHLOROPHENETHYLAMINE
• Synonyms: RARECHEM AL BW 0050;TIMTEC-BB SBB003665;2-(2,6-DICHLOROPHENYL)ETHANAMINE;2-(2,6-DICHLOROPHENYL)ETHYLAMINE;2-(2-AMINOETHYL)-1,3-DICHLOROBENZENE;2,6-DICHLOROPHENETHYLAMINE;1-AMINO-2-(2,6-DICHLOROPHENYL)ETHANE;2,6-DICHLOROPHENETHYLAMINE 99%
• CAS NO: 14573-23-0
• Molecular Formula: C₈H₉Cl₂N
• Molecular Weight: 190.07
• Product Categories: Amines;C8;Nitrogen Compounds;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 14573-23-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 125-129 °C52.5 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: clear colorless to slightly yellow liquid
• Density: 1.307 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00865mmHg at 25°C
• Refractive Index: n20/D 1.5690(lit.)
• PKA: 9.19±0.10(Predicted)
• CAS DataBase Reference: 2,6-DICHLOROPHENETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DICHLOROPHENETHYLAMINE(14573-23-0)
• EPA Substance Registry System: 2,6-DICHLOROPHENETHYLAMINE(14573-23-0)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38
• Safety Statements: 26
• RIDADR: 2735
• WGK Germany: 3
• HazardClass: IRRITANT, TOXIC
• Hazardous Substances Data: 14573-23-0(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to slightly yellow liquid

Uses

2,6-Dichlorophenethylamine, a phenethylamine derivative, may be used to synthesize C-terminal phenethylamine peptide analog.

InChI:InChI=1/C8H9Cl2N/c9-7-2-1-3-8(10)6(7)4-5-11/h1-3H,4-5,11H2/p+1

Upstream product

• 3215-64-3 2,6-dichlorophenylacetonitrile 
• 52287-52-2 2,6-dichloronitrostyrene 
• 83-38-5 2,6-dichlorobenzaldehyde 

Downstream Products

• 26011-72-3 N-(2,6-dichlorophenethyl)acetamide 
• 79988-70-8 5,5-methylenebis-2,4,6-triaminopyrimidine 
• 79988-69-5 6-[2-(2,6-Dichloro-phenyl)-ethyl]-5,6,7,8-tetrahydro-pyrimido[4,5-d]pyrimidine-2,4-diamine 
• 85176-59-6 N-methyl-N-[2-(2,6-dichloro-phenyl)-ethyl]-amine 
• 950502-25-7 [2-(2,6-dichloro-phenyl)-ethyl]-(3-iodo-benzyl)-amine 
• 1222374-92-6 C₉H₁₀Cl₂N₂S 
• 950501-83-4 [3-({tert-butoxycarbonyl-[2-(2,6-dichloro-phenyl)-ethyl]-amino}-methyl)-phenyl]-acetic acid 
• 950502-33-7 [2-(2,6-dichloro-phenyl)-ethyl]-[3-(2-oxo-propyl)-benzyl]-carbamic acid tert-butyl ester 
• 950502-29-1 [2-(2,6-dichloro-phenyl)-ethyl]-[3-(3-oxo-propyl)-benzyl]-carbamic acid tert-butyl ester 
• 950502-27-9 [2-(2,6-dichloro-phenyl)-ethyl]-(3-iodo-benzyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Design, synthesis and evaluation of thiourea derivatives as antimicrobial and antiviral agents

Background: The development of drug-resistant by bacteria appears rapidly and thus making the effectiveness of antibiotics severely limited. Methods: A series of thiourea derivatives was synthesized, characterized and evaluated for their in vitro antibacterial, antifungal and antiviral activities. Results: Structures of the newly synthesized compounds were confirmed by elemental and spectral analysis. The biological results showed that some of the target compounds displayed comparable antimicrobial and antiviral activities with reference drugs. Structure-activity relationship studies revealed that the ortho-chloro or fluoro substituted phenyl at Ar1 and substituted pyridinyl at Ar2 positions of the thiourea nucleus are essential for their in vitro antimicrobial and anti-HIV activity. In particular, compounds 8 and 10 showed better activity against the tested bacteria, fungi and viral strains than other synthesized PET derivatives reported in the present study. Conclusion: These results provide an encouraging lead that could be used for the development of new potent antiviral and antimicrobial agents.

Synthesis and antihypertensive activity of 2-arylamino-1-azacycloalkenes.

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