145743-63-1

Basic information

• Product Name: 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-methyl-5-oxo-N-(3-pyridinylmethyl)-1-pyrazolidine carboxamide
• Synonyms: 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-methyl-5-oxo-N-(3-pyridinylmethyl)-1-pyrazolidine carboxamide
• CAS NO: 145743-63-1
• Molecular Weight: 424.5
• Mol File: 145743-63-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-methyl-5-oxo-N-(3-pyridinylmethyl)-1-pyrazolidine carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-methyl-5-oxo-N-(3-pyridinylmethyl)-1-pyrazolidine carboxamide(145743-63-1)
• EPA Substance Registry System: 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-methyl-5-oxo-N-(3-pyridinylmethyl)-1-pyrazolidine carboxamide(145743-63-1)

Safety Data

• Hazardous Substances Data: 145743-63-1(Hazardous Substances Data)

Upstream product

• 75-44-5 phosgene 
• 145743-48-2 5-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-methyl-3-pyrazolidinone 

Relevant articles and documents

Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents

There are disclosed compounds of the formula STR1 wherein R1 is hydrogen or lower alkyl; R2 is C3-7 alkyl or C3-7 cycloalkyl; R3 is hydrogen, lower alkyl, carboxyloweralkyl, lower alkoxycarbonyl, lower alkoxycarbonyl loweralkyl, aryl or aralkyl; R4 is hydrogen, C1-8 alkyl, STR2 B is a bond, NH or O; Y is O or S; A is a bond or --C=C--; n is 0-5; R5 is hydrogen when B is NH, or R5 is lower alkyl, C3-8 cycloalkyl; aryl, substituted aryl, aralkyl, substituted aralkyl, aralkenyl, aralkenylalkyl or STR3 R6 is hydrogen or halo; the dotted line represents an optional double bond; and the pharmacologically acceptable salts thereof, which by virtue of their ability to selectively inhibit PDE IV, are bronchodilatory and anti-inflammatory and so are useful in the treatment of acute and chronic bronchial asthma and associated pathologies.