145744-11-2Relevant academic research and scientific papers
Synthesis of pancratistatin models
Lopes,Lopes,Heathcock
, p. 6775 - 6778 (2007/10/02)
Two model syntheses for the phenanthridone core of the cytotoxic alkaloid pancratistatin are reported. The key maneuver in these syntheses is 1,4-addition of an ortho-lithiated benzamide derivative to 1-nitrocyclohexene. The resulting 2-aryl-1-nitrocyclohexanes (6 and 11) are further transformed into the pancratistatin models 2 and 3.
