145783-13-7

Basic information

• Product Name: 5-nitro-2-(propylthio)pyriMdine-4,6-diol
• Synonyms: 5-nitro-2-(propylthio)pyriMdine-4,6-diol;5-Nitro-2-(propylthio)pyriMidine-4,6-diol;4(3H)-PyriMidinone, 6-hydroxy-5-nitro-2-(propylthio)-;S-Propyl-5-nitro-2-thiobarbituric Acid;4-hydroxy-5-nitro-2-propylsulfanyl-1H-pyrimidin-6-one
• CAS NO: 145783-13-7
• Molecular Formula: C₇H₉N₃O₄S
• Molecular Weight: 231.22906
• EINECS: -0
• Mol File: 145783-13-7.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• Density: 1.65±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.21±0.10(Predicted)
• CAS DataBase Reference: 5-nitro-2-(propylthio)pyriMdine-4,6-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-nitro-2-(propylthio)pyriMdine-4,6-diol(145783-13-7)
• EPA Substance Registry System: 5-nitro-2-(propylthio)pyriMdine-4,6-diol(145783-13-7)

Safety Data

• Hazardous Substances Data: 145783-13-7(Hazardous Substances Data)

Usage

General Description

5-nitro-2-(propylthio)pyrimidine-4,6-diol is a chemical compound with potential scientific and industrial applications. Its properties are related to its specific molecular structure and the features of its constituent elements, such as nitrogen, sulfur, oxygen, carbon, and hydrogen. As the compound combines different functional groups - nitro, propylthio, pyrimidine, and diol - it suggests a range of potential chemical interactions. Conditional on the specifications of the compound's synthesis it could potentially be used as an intermediate in certain chemical reactions, or as a precursor to various substances in the areas of pharmaceuticals or materials science. Further research will be necessary to fully elucidate its characteristics, reactivity, and potential functionality.

Upstream product

• 187666-88-2 2-(Propylthio)-4,6(1H,5H)-pyrimidinedione 
• 107-08-4 1-iodo-propane 
• 106-94-5 propyl bromide 
• 145783-12-6 4,6-dihydroxy-2-(propylsulfanyl)pyrimidine 

Downstream Products

• 145783-14-8 4,6-dichloro-5-nitro-2-(propylsulfanyl)pyrimidine 
• 1621679-05-7 4,6-dibromo-2-(propylthio)5-amino-pyrimidine 

Relevant articles and documents

Method for synthesizing 5-nitro-2-(propylthio) pyrimidine-4, 6-diol through continuous nitration

The invention discloses a method for synthesizing 5-nitro-2-(propyl thio) pyrimidine-4, 6-diol through continuous nitration. The synthesis method comprises the following steps: in a continuous flow reactor, taking nitrogen dioxide as a main nitrating agent, ozone as an auxiliary nitrating agent and 4, 6-dihydroxy-2-(propylthio) pyrimidine hydrochloride as a main raw material, carrying out nitration reaction to prepare the 5-nitro-2-(propylthio) pyrimidine-4, 6-diol compound. The method is extremely low in EHS risk, simple and convenient to operate, environment-friendly, high in production efficiency, high in yield, high in purity and suitable for industrial production.

Design, synthesis and in vitro biological evaluation of novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing a thiosemicarbazide moiety

A series of hybrid molecules containing [1,2,3]triazolo[4,5-d]pyrimidine and thiosemicarbazide moieties were designed, synthesized and evaluated for their antiproliferative activities against MGC-803, NCI-H1650 and PC-3 human cancer cells. Some of the synthesized compounds showed moderate to good activity against three selected cancer cell lines. Among these compounds, compound 29 displayed the most potent antiproliferative activity as well as good selectivity between cancer cells and normal cells. Further mechanism studies revealed that compound 29 could obviously inhibit the colony formation and migration of MGC-803 as well as induced apoptosis.

Pyrimidotriazole-containing LSD1 inhibitor, preparation method and application

Belonging to the field of pharmaceutical chemistry, the invention discloses a pyrimidotriazole compound, a preparation method and application of the compound with lysine specific demethylase 1 (LSD1) as the target in preparation of antitumor drugs. The general formula of the compound is shown as I in the specification. In vitro LSD1 enzyme inhibitory activity experiments prove that by inhibiting the activity of LSD1, the compound has obvious inhibition and killing effects on multiple tumor cells, can be applied as a lead compound for further development in preparation of antitumor drugs.