1457998-41-2Relevant academic research and scientific papers
Total synthesis of γ-trifluoromethylated analogs of goniothalamin and their derivatives
Chen, Jun-Ling,You, Zheng-Wei,Qing, Feng-Ling
, p. 143 - 150 (2013/10/01)
An efficient method for the construction of chiral γ- trifluoromethylated α,β-unsaturated δ-lactone, a widely existing pharmacophore, has been developed and successfully applied for synthesis of γ-trifluoromethylated goniothalamins. The key steps included Evans-Aldol reaction of chiral titanium enolate of α-CF3 imide, Wittig olefination and lactonization. The transformation of γ-trifluoromethylated α,β-unsaturated δ-lactone to a series of trifluoromethylated styryllactones was also investigated.
