883454-11-3Relevant academic research and scientific papers
Highly stereoselective TiCl4-catalyzed Evans-aldol and Et 3Al-mediated Reformatsky reactions. Efficient accesses to optically active syn- or anti-α-trifluoromethyl-β-hydroxy carboxylic acid derivatives
Shimada, Taichi,Yoshioka, Masamitsu,Konno, Tsutomu,Ishihara, Takashi
, p. 1129 - 1131 (2006)
The TiCl4-catalyzed Evans-aldol reaction of optically active 3,3,3-trifluoropropanoic imide gave the non-Evans syn product stereoselectively, whereas the Reformatsky reaction of 2-bromo-3,3,3-trifluoropropanoic imide in the presence of Et3
Total synthesis of γ-trifluoromethylated analogs of goniothalamin and their derivatives
Chen, Jun-Ling,You, Zheng-Wei,Qing, Feng-Ling
, p. 143 - 150 (2013/10/01)
An efficient method for the construction of chiral γ- trifluoromethylated α,β-unsaturated δ-lactone, a widely existing pharmacophore, has been developed and successfully applied for synthesis of γ-trifluoromethylated goniothalamins. The key steps included Evans-Aldol reaction of chiral titanium enolate of α-CF3 imide, Wittig olefination and lactonization. The transformation of γ-trifluoromethylated α,β-unsaturated δ-lactone to a series of trifluoromethylated styryllactones was also investigated.
