145801-71-4Relevant academic research and scientific papers
The synthesis of polyfunctional gamma-lactams and perhydro-1,2-pyridazin-3-ones
Amri,El Gaied,Ben Ayed,Villieras
, p. 7345 - 7346 (1992)
Direct condensation, in methanol, of primary amines on 2-(1-carbethoxy-1-hydroxyethyl)acrylonitrile yielded to α and β-functionalized γ-lactames 6(a-f). The same reaction with hydrazines gave perhydro-1,2-pyridazin-3-ones 7 and 8 when nitrogen is not dial
Conjugated addition of primary amines on acrylic α-(1-hydroxy)alkyl: New synthesis of polyfunctional β- and γ-lactames
Ben Ayed,Amri,El Gaied,Villieras
, p. 9633 - 9642 (2007/10/02)
Direct condensation, in methanol, of primary amines on ethyl-α-(1-hydroxyalkyl)acrylates and 2-(1-carbethoxy-1-hydroxyethyl)acrylonitrile yielded respectively to α-(1-hydroxyalkyl)-β-lactames and α,β-difunctionalized γ-lactames in good to fair yields. In the latter case, reaction with N,N-dialkylated hydrazines gave perhydro-1,2-pyridazinones.
