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1458056-08-0

N-(4-(3-fluorophenyl) thiazol-2-yl)-2-(1,2-dihydro-2-methyl-1-oxophthalazin-4-yl)acetamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1458056-08-0 Structure

  • Basic information

    1. Product Name: N-(4-(3-fluorophenyl) thiazol-2-yl)-2-(1,2-dihydro-2-methyl-1-oxophthalazin-4-yl)acetamide
    2. Synonyms: N-(4-(3-fluorophenyl) thiazol-2-yl)-2-(1,2-dihydro-2-methyl-1-oxophthalazin-4-yl)acetamide
    3. CAS NO:1458056-08-0
    4. Molecular Formula:
    5. Molecular Weight: 394.429
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1458056-08-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(4-(3-fluorophenyl) thiazol-2-yl)-2-(1,2-dihydro-2-methyl-1-oxophthalazin-4-yl)acetamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(4-(3-fluorophenyl) thiazol-2-yl)-2-(1,2-dihydro-2-methyl-1-oxophthalazin-4-yl)acetamide(1458056-08-0)
    11. EPA Substance Registry System: N-(4-(3-fluorophenyl) thiazol-2-yl)-2-(1,2-dihydro-2-methyl-1-oxophthalazin-4-yl)acetamide(1458056-08-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1458056-08-0(Hazardous Substances Data)

1458056-08-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1458056-08-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,8,0,5 and 6 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1458056-08:
(9*1)+(8*4)+(7*5)+(6*8)+(5*0)+(4*5)+(3*6)+(2*0)+(1*8)=170
170 % 10 = 0
So 1458056-08-0 is a valid CAS Registry Number.

1458056-08-0Downstream Products

1458056-08-0Relevant articles and documents

Discovery of thiazolyl-phthalazinone acetamides as potent glucose uptake activators via high-throughput screening

Agrawal, Madhavi,Kharkar, Prashant,Moghe, Sonali,Mahajan, Tushar,Deka, Vaishali,Thakkar, Chandni,Nair, Amrutha,Mehta, Chirag,Bose, Julie,Kulkarni-Almeida, Asha,Bhedi, Dilip,Vishwakarma, Ram A.

, p. 5740 - 5743 (2013/10/01)

With the aim to discover orally active small molecules that stimulate glucose uptake, high throughput screening of a library of 5000 drug-like compounds was conducted in differentiated skeletal muscle cells in presence of insulin. N-Substituted phthalazinone acetamide was identified as a potential glucose uptake modulator. Several novel derivatives were synthesized to establish structure activity relationships. Identified lead thiazolyl- phthalazinone acetamide (7114863) increased glucose uptake (EC50 of 0.07 ± 0.02 μM) in differentiated skeletal muscle cells in presence of insulin. Furthermore, 7114863 was superior to rosiglitazone under similar experimental conditions without inducing PPAR-γ agonist activity thus making it a very interesting scaffold.

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