1458056-27-3

Basic information

• Product Name: N-(5-(4-fluorophenyl)isoxazol-3-yl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl) acetamide
• Synonyms: N-(5-(4-fluorophenyl)isoxazol-3-yl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl) acetamide
• CAS NO: 1458056-27-3
• Molecular Weight: 378.363
• Mol File: 1458056-27-3.mol

Chemical Properties

• CAS DataBase Reference: N-(5-(4-fluorophenyl)isoxazol-3-yl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl) acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-(4-fluorophenyl)isoxazol-3-yl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl) acetamide(1458056-27-3)
• EPA Substance Registry System: N-(5-(4-fluorophenyl)isoxazol-3-yl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl) acetamide(1458056-27-3)

Safety Data

• Hazardous Substances Data: 1458056-27-3(Hazardous Substances Data)

Upstream product

• 925005-35-2 5-(4-fluorophenyl)-3-aminoisoxazole 
• 25947-11-9 1,2-Dihydro-1-oxophthalazin-4-ylacetic acid 
• 25947-13-1 ethyl 1,2-dihydro-1-oxophthalazin-4-ylacetate 
• 57691-07-3 ethyl [(E)-3-oxo-1,3-dihydroisobenzofuran-1-ylidene]acetate 
• 85-44-9 phthalic anhydride 

Relevant articles and documents

Discovery of thiazolyl-phthalazinone acetamides as potent glucose uptake activators via high-throughput screening

With the aim to discover orally active small molecules that stimulate glucose uptake, high throughput screening of a library of 5000 drug-like compounds was conducted in differentiated skeletal muscle cells in presence of insulin. N-Substituted phthalazinone acetamide was identified as a potential glucose uptake modulator. Several novel derivatives were synthesized to establish structure activity relationships. Identified lead thiazolyl- phthalazinone acetamide (7114863) increased glucose uptake (EC50 of 0.07 ± 0.02 μM) in differentiated skeletal muscle cells in presence of insulin. Furthermore, 7114863 was superior to rosiglitazone under similar experimental conditions without inducing PPAR-γ agonist activity thus making it a very interesting scaffold.