145874-03-9Relevant academic research and scientific papers
Synthesis and biological properties of 1,8-naphthalimidebutylamines. Serotonin 5-HT1A and 5-HT7 binding data and PASS-assisted search
Kowalski, Piotr,Kowalska, Teresa,Bojarski, Andrzej J.,Duszynska, Beata
, p. 889 - 893 (2007)
(Chemical Equation Presented) Syntheses of the N-substituted butyl derivatives of 1,8-naphthalimide (1-8), containing various arylpiperazines, tetrahydroisoquinoline and methylhomopiperazine moieties attached at 4-position of the butyl chain have been described. Biological activities were evaluated in vitro for their ability to bind to serotonin 5-HT1A and 5-HT 7 receptors. Due to the structural similarity of derivatives 1-8 to psychotropic agents, the pharmacological properties of target compounds were predicted using PASS program.
2-(Piperidinyl or tetrahydropyridinyl)-alkyl)-2,3-dihydro-3-hydroxy-1H-benz(DE)isoquinolin-1-ones
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, (2008/06/13)
Compounds of the following formula STR1 wherein R1 and R2 are selected from hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, trifluoromethyl, nitro, amino and cyano; Z is selected from STR2 R3 is selected fro
