145881-74-9Relevant articles and documents
Synthetic Rhamnose Glycopolymer Cell-Surface Receptor for Endogenous Antibody Recruitment
De Coen, Ruben,Nuhn, Lutz,Perera, Chamani,Arista-Romero, Maria,Risseeuw, Martijn D. P.,Freyn, Alec,Nachbagauer, Raffael,Albertazzi, Lorenzo,Van Calenbergh, Serge,Spiegel, David A.,Peterson, Blake R.,De Geest, Bruno G.
, p. 793 - 802 (2020)
Synthetic materials capable of engineering the immune system are of great relevance in the fight against cancer to replace or complement the current monoclonal antibody and cell therapy-based immunotherapeutics. Here, we report on antibody recruiting glyc
COMPOUNDS AND THERAPEUTIC USES THEREOF
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Page/Page column 67-68, (2020/05/19)
The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating cancer and infectious diseases, to compositions containing said compounds, processes for their preparation and to novel intermediates used in said process.
Camptothecin sugar derivative and preparation method and application thereof
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Paragraph 0054-0056; 0058, (2019/11/13)
The invention relates to a camptothecin sugar derivative and a preparation method and application thereof, and belongs to the field of biological medicines. The structural formula of the camptothecinsugar derivative is shown in formula (I) in specification. The camptothecin sugar derivative can obviously improve the stability and water solubility of camptothecin and 10-hydroxycamptothecin, and has different sensitivities to different tumor cells. Especially when the chain link n equals to 1, the camptothecin sugar derivative of the invention can significantly increase the selectivity to tumorcells.