145915-58-8

Basic information

• Product Name: DAPH
• Synonyms: 4,5-Dianilinophthalimide, 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione, CGP 52411;DAPH/CGP 52411
• CAS NO: 145915-58-8
• Molecular Formula: C₂₀H₁₅N₃O₂
• Molecular Weight: 329.358
• EINECS: 406-050-3
• Mol File: 145915-58-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 199-202℃
• Appearance: orange/solid
• Density: 1.374
• Storage Temp.: 2-8°C
• Solubility: DMSO: ~30 mg/mL
• PKA: 9.06±0.20(Predicted)
• CAS DataBase Reference: DAPH(CAS DataBase Reference)
• NIST Chemistry Reference: DAPH(145915-58-8)
• EPA Substance Registry System: DAPH(145915-58-8)

Safety Data

• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 145915-58-8(Hazardous Substances Data)

Usage

Uses

CGP 52411 is a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitmuor activity. It may offer therapeutic agents for the treatment of hyperproliferative diseases.

Biochem/physiol Actions

DAPH is an inhibitor of Aβ fibril formation; Protein tyrosine kinase inhibitor, specific for EGFR.

Upstream product

• 159715-92-1 4,5-bis(anilino)phthalic anhydride 
• 62-53-3 aniline 
• 106727-86-0 4,5-dichlorophthalic acid dimethyl ester 
• 56962-08-4 4,5-dichlorophthalic acid 
• 130672-95-6 4,5-bis(phenylamino)phthalic acid dimethyl ester 

Downstream Products

• 145916-00-3 4-anilino-5-(4-methoxy-anilino)-phthalimide 

Relevant articles and documents

Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's Disease via palladium-catalyzed animation

DAPH (4,5-dianilinophthalimide) has previously been shown to reverse the formation of neurotoxic fibrils associated with Alzheimer's disease. We have developed a synthetic route to DAPH and structurally related analogues that employs palladium-catalyzed a

Dianilinophthalimides: Potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase

Dianilinophthalimides represent a novel class of inhibitors of the EGF- receptor protein tyrosine kinase with a high degree of selectivity versus other tyrosine and serine/threonine kinases. Steady-state kinetic analysis of compound 3, which showed potent