1459213-50-3

Basic information

• Product Name: (1R)-(+)-1-(9H-fluoren-9-yl)ethyl acetate
• CAS NO: 1459213-50-3
• Molecular Weight: 252.313
• Mol File: 1459213-50-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R)-(+)-1-(9H-fluoren-9-yl)ethyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-(+)-1-(9H-fluoren-9-yl)ethyl acetate(1459213-50-3)
• EPA Substance Registry System: (1R)-(+)-1-(9H-fluoren-9-yl)ethyl acetate(1459213-50-3)

Safety Data

• Hazardous Substances Data: 1459213-50-3(Hazardous Substances Data)

Upstream product

• 108-05-4 vinyl acetate 
• 3023-49-2 9-(1-hydroxyethyl)fluorene 
• 3300-10-5 9-acetylfluorene 
• 86-73-7 9H-fluorene 

Relevant articles and documents

First chemoenzymatic synthesis of (R)- and (S)-1-(9H-fluoren-9-yl)ethanol

A simple chemoenzymatic synthesis of 1-(9H-fluoren-9-yl)ethanol stereoisomers is described. The enantiomers were resolved by a kinetically controlled transesterification with vinyl acetate in the presence of commercially available lipases. High-throughput screening and subsequent exhaustive investigation of the utility of the lipases in a stereoselective process of introducing chirality have been carried out. Lipase A from Candida antarctica as a cross-linked aggregate (CAL-A-CLEA) was the most efficient enzyme for the resolution of the title compound providing (S)-1-(9H-fluoren-9- yl)ethanol and its (R)-acetate in enantiopure form (>99% ee). Under mild reaction conditions, excellent enantioselectivity (E = 407), and good isolated yields of the products were obtained.