145958-73-2Relevant academic research and scientific papers
Palladium-Catalyzed Intramolecular Alkyne-Carbon Monoxide-Alkene Insertion Cascade for Synthesis of α-Methylenecyclopentenones
Ihle, Nathan C.,Heathcock, Clayton H.
, p. 560 - 563 (2007/10/02)
A method for the construction of α-methylenecyclopentenones fused to five-membered rings using a palladium catalyst is reported.The procedure involves the formation of ?-allylpalladium intermediates that undergo sequential intramolecular alkyne insertion, carbon monoxide insertion, intramolecular alkene insertion, and β-hydride elimination.Examples of the cyclization are seen in eq 2 and Scheme III.
