1460307-57-6

Basic information

• Product Name: C₃₈H₄₇N₃O₈
• Synonyms: C₃₈H₄₇N₃O₈
• CAS NO: 1460307-57-6
• Molecular Weight: 673.806
• Mol File: 1460307-57-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₈H₄₇N₃O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₈H₄₇N₃O₈(1460307-57-6)
• EPA Substance Registry System: C₃₈H₄₇N₃O₈(1460307-57-6)

Safety Data

• Hazardous Substances Data: 1460307-57-6(Hazardous Substances Data)

Upstream product

• 533-58-4 2-Iodophenol 
• 1194057-63-0 (2S,4R)-tert-butyl 4-(benzyloxycarbonylamino)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 1460303-63-2 C₂₄H₂₉IN₂O₅ 

Downstream Products

• 1460307-59-8 C₂₉H₃₁N₃O₆*C₂HF₃O₂ 
• 1460305-27-4 benzyl N-[(15R,16aS)-10-methyl-9,12-dioxo-9,10,11,12,15,16,16a,17-octahydro-14H-dibenzo[i,k ]pyrrolo[2,1-c][1,4,7]oxadiazacyclododecin-15-yl]carbamate 

Relevant articles and documents

CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS

The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), inhibitory activity on enzymes or antimicrobial activity. In particular, these macrocycles show inhibitory activity on endothelin converting enzyme of subtype 1 (ECE-1) and/or the cysteine protease cathepsin S (CatS), and/or act as antagonists of the oxytocin (OT) receptor, thyrotropin-releasing hormone (TRH) receptor and/or leukotriene B4 (LTB4) receptor, and/or as agonists of the bombesin 3 (BB3) receptor, and/or show antimicrobial activity against at least one bacterial strain. Thus they are showing great potential as medicaments for a variety of diseases.