1194057-63-0

Basic information

• Product Name: (2S,4R)-4-BenzyloxycarbonylaMino-2-hydroxyMethyl-pyrrolidine-1-carboxylic acid tert-butyl ester
• Synonyms: (2S,4R)-4-BenzyloxycarbonylaMino-2-hydroxyMethyl-pyrrolidine-1-carboxylic acid tert-butyl ester;(2S,4R)-tert-Butyl 4-(((benzyloxy)carbonyl)aMino)-2-(hydroxyMethyl)pyrrolidine-1-carboxylate;(2S,4R)-1-BOC-2-hydroxymethyl-4-CBZ-amino Pyrrolidine
• CAS NO: 1194057-63-0
• Molecular Formula: C₁₈H₂₆N₂O₅
• Molecular Weight: 350.40944
• Mol File: 1194057-63-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (2S,4R)-4-BenzyloxycarbonylaMino-2-hydroxyMethyl-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-4-BenzyloxycarbonylaMino-2-hydroxyMethyl-pyrrolidine-1-carboxylic acid tert-butyl ester(1194057-63-0)
• EPA Substance Registry System: (2S,4R)-4-BenzyloxycarbonylaMino-2-hydroxyMethyl-pyrrolidine-1-carboxylic acid tert-butyl ester(1194057-63-0)

Safety Data

• Hazardous Substances Data: 1194057-63-0(Hazardous Substances Data)

Usage

General Description

The chemical (2S,4R)-4-BenzyloxycarbonylaMino-2-hydroxyMethyl-pyrrolidine-1-carboxylic acid tert-butyl ester is a compound that belongs to the class of pyrrolidine carboxylic acid derivatives. It has a molecular formula of C22H30N2O5 and a molecular weight of 402.488 g/mol. This chemical is commonly used as a building block for the synthesis of various pharmaceutical compounds and can also be used as a chiral auxiliary in asymmetric synthesis. It is important to handle this compound with caution and in accordance with proper safety protocols, as it can pose health risks if mishandled.

Upstream product

• 1279038-50-4 (2S,4R)-tert-butyl 4-amino-2-(hydroxymethyl)pyrrolidine-1-carboxylate hydrochloride 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1460303-63-2 C₂₄H₂₉IN₂O₅ 
• 1460307-57-6 C₃₈H₄₇N₃O₈ 
• 1194057-65-2 ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-hydroxymethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1194057-67-4 ethyl (3aS,5R)-5-benzyloxycarbonylamino-13-cyclopropyl-8-fluoro-10-oxo-3a,4,5,6,10,13-hexahydro-1H,3H-pyrrolo[2',1':3,4][1,4]oxazepino[5,6-h]quinoline-11-carboxylate 
• 1194057-64-1 ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-fomyl-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1460305-27-4 benzyl N-[(15R,16aS)-10-methyl-9,12-dioxo-9,10,11,12,15,16,16a,17-octahydro-14H-dibenzo[i,k ]pyrrolo[2,1-c][1,4,7]oxadiazacyclododecin-15-yl]carbamate 
• 1194057-62-9 benzyl ((3R,5S)-5-(hydroxymethyl)pyrrolidin-3-yl)carbamate hydrochloride 

Relevant articles and documents

CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS

The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), inhibitory activity on enzymes or antimicrobial activity. In particular, these macrocycles show inhibitory activity on endothelin converting enzyme of subtype 1 (ECE-1 ) and/or the cysteine protease cathepsin S (CatS), and/or act as antagonists of the oxytocin (OT) receptor, thyrotropin-releasing hormone (TRH) receptor and/or leukotriene B4 (LTB4) receptor, and/or as agonists of the bombesin 3 (BB3) receptor, and/or show antimicrobial activity against at least one bacterial strain. Thus they are showing great potential as medicaments for a variety of diseases.