14605-97-1

Upstream product

• 88-74-4 2-nitro-aniline 
• 14715-65-2 4-bromo-3-(2-nitrophenyl)sydnone 
• 121163-60-8 N-(2-nitro-phenyl)-N-nitroso-glycine 
• 108-24-7 acetic anhydride 

Downstream Products

• 14715-65-2 4-bromo-3-(2-nitrophenyl)sydnone 
• 34315-03-2 3-(2-Aminophenyl)sydnone 
• 104273-17-8 3-(2-amino-5-bromophenyl)sydnone 
• 104273-16-7 4-bromo-3-(2-amino-5-bromophenyl)sydnone 
• 104273-21-4 3-(2-acetamidophenyl)sydnone 
• 104273-22-5 3-<2-(Trifluoroacetamido)phenyl>sydnone 
• 34315-04-3 3-(2-methylamino-phenyl)-sydnone 
• 11094-28-3 5-benzyl-3,4-dioxo-1,3,4,5-tetrahydro-[1,2,3]oxadiazolo[3,4-a]quinoxalinylium betaine 
• 34315-05-4 3-(2-benzylamino-phenyl)-sydnone 
• 86532-26-5 <2-18F>Fluoronitrobenzene 

Relevant academic research and scientific papers

Microwave-assisted synthesis of N-arylglycines: Improvement of sydnone synthesis

Reactions of anilines with ethyl bromoacetate under microwave irradiation have afforded N-arylglycines that are subsequently converted to their N-nitroso derivatives with a combination of silica chloride or periodic acid, wet SiO2 and sodium nitrite in CH2Cl2 with satisfactory yields. In the final step, the use of 1,3-dibromo-5,5-dimethylhydantoin (DBH) as a new and effective reagent for dehydration of N-nitroso-N-arylglycines to sydnones was successfully examined.

Synthesis and evaluation of phenyl substituted sydnones as potential DPPH-radical scavengers

A series of phenyl substituted sydnones has been synthesized and their radical-scavenging activity has been studied on DPPH free radical. Out of eighteen compounds screened, nine compounds show interesting activity. A mechanism is presented whereby sydnones scavenge DPPH radical through donating H-atom at 4th-position. Its strong radical-scavenging activity mainly arises from 1, 2, 3-oxadiazolium-5-olate ring. Different substituents and their positions on the phenyl ring differently influence DPPH scavenging activity and therefore, may provide clues to design and develop better free-radical scavenging sydnones with multiple activities.

DEBROMINATION OF 4-BROMO-3-ARYLSYDNONES WITH SODIUM SULFITE

4-Bromo-3-arylsydnones 1 are debrominated to the corresponding 3-arylsydnones 2 in good to excellent yield using sodium sulfite in methanol/water.In contrast to previously employed reagents, the reaction is successful in the presence of electron-donating,

The Efficient Synthesis of 3-Arylsydnones Under Neutral Conditions

Various substituted aryl sydnones can be prepared in high yield under mild, neutral conditions by nitrosation of the appropriate aryl glycine with isoamyl nitrite in dimethoxyethane followed by cyclization with trifluoroacetic anhydride.

DEBROMINATION OF 4-BROMO-3-ARYLSYDNONES WITH SODIUM DITHIONITE.

A variety of 4-bromo-3-arylsydnones can be debrominated with sodium dithionite in excellent yield under very mild conditions.

Debromination of 3-Aryl-4-bromosydnones with Sodium Borohydride

Debromination of 4-bromo-3-(2-substituted aryl) sydnones 1 with sodium borohydride in methanol occurs readily to give good yields of the corresponding parent sydnones 2, except in those cases where the aryl substituent also reacts.The utility of the proce