146062-45-5

Basic information

• Product Name: 5-[[4-[2-(5-ACETYL-2-PYRIDINYL)ETHOXY]PHENYL]METHYL]-2,4THIAZOLIDINEDIONE
• Synonyms: 5-[[4-[2-(5-ACETYL-2-PYRIDINYL)ETHOXY]PHENYL]METHYL]-2,4THIAZOLIDINEDIONE;Keto Pioglitazone Discontinued see product # K200600;Keto-Pioglitazone (M-III);Keto Pioglitazone;Keto PioglitazoneSee product # K200600;Pioglitazone, ketone;Keto Pioglitazone See K200600;Pioglitazone ketone metabolite
• CAS NO: 146062-45-5
• Molecular Formula: C19H18N2O4S
• Molecular Weight: 370.42
• Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Aromatics;Heterocycles;Sulfur & Selenium Compounds
• Mol File: 146062-45-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 113-115°C
• Boiling Point: 623.8 °C at 760 mmHg
• Flash Point: 331.1 °C
• Appearance: /
• Density: 1.315 g/cm³
• Vapor Pressure: 1.75E-15mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 6.35±0.50(Predicted)
• CAS DataBase Reference: 5-[[4-[2-(5-ACETYL-2-PYRIDINYL)ETHOXY]PHENYL]METHYL]-2,4THIAZOLIDINEDIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[[4-[2-(5-ACETYL-2-PYRIDINYL)ETHOXY]PHENYL]METHYL]-2,4THIAZOLIDINEDIONE(146062-45-5)
• EPA Substance Registry System: 5-[[4-[2-(5-ACETYL-2-PYRIDINYL)ETHOXY]PHENYL]METHYL]-2,4THIAZOLIDINEDIONE(146062-45-5)

Safety Data

• Hazardous Substances Data: 146062-45-5(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

InChI:InChI=1/C19H18N2O4S/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17/h2-7,11,17H,8-10H2,1H3,(H,21,23,24)

Upstream product

• 146062-60-4 methyl 2-bromo-3-<4-<2-<5-(1-memthoxymethoxyethyl)-2-pyridyl>ethoxy>phenyl>propionate 
• 146062-58-0 2-<5-(1-methoxymethoxyethyl)-2-pyridyl>ethanol 
• 146062-57-9 3-(1-(methoxymethoxy)ethyl)-6-methylpyridine 
• 56019-64-8 5-(1-hydroxyethyl)-2-methylpyridine 
• 184766-62-9 5-[1-(4-{2-[5-(2-Methyl-[1,3]dioxolan-2-yl)-pyridin-2-yl]-ethoxy}-phenyl)-meth-(Z)-ylidene]-thiazolidine-2,4-dione 
• 184766-55-0 4-{2-[5-(2-methyl-1,3-dioxolan-2-yl)-2-pyridyl]ethoxy}benzaldehyde 
• 184766-50-5 2-[5-(2-methyl-1,3-dioxolan-2-yl)-2-pyridyl]ethanol 
• 184766-45-8 3-(2-methyl-1,3-dioxolan-2-yl)-6-methylpyridine 
• 21683-58-9 ethyl 3-(2-methyl-5-pyridinyl)-3-oxopropanoate 
• 5470-70-2 Methyl 6-methylnicotinate 
• 36357-38-7 1-(6-methyl-pyridin-3-yl)-ethanone 
• 184766-66-3 5-(4-{2-[5-(2-Methyl-[1,3]dioxolan-2-yl)-pyridin-2-yl]-ethoxy}-benzyl)-thiazolidine-2,4-dione 
• 146062-44-4 Hydroxypioglitazone 
• 1026292-59-0 2-Imino-5-(4-{2-[5-(1-methoxymethoxy-ethyl)-pyridin-2-yl]-ethoxy}-benzyl)-thiazolidin-4-one 

Relevant articles and documents

USE OF 5-[[4-[2-[5-ACETYLPYRIDIN-2-YL]ETHOXY]BENZYL]-1,3-THIAZOLIDINE-2,4-DIONE AND ITS SALTS

The present disclosure relates to a method of treating or preventing a disease or disorder selected from the group consisting of a central nervous system disorder, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, a chronic granulomatous dis

Studies on antidiabetic agents. XII. Synthesis and activity of the metabolites of (±)-5-[p-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl]-2,4- thiazolidinedione (pioglitazone)

The metabolites of (±)-5-[p-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl]-2,4- thiazolidinedione (1, pioglitazone), which is a representative insulin- sensitizing agent, were synthesized to confirm their structures and for studies of their pharmacological properti