146096-65-3Relevant academic research and scientific papers
C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: A tether length study
Goulet, Mark T.,Sinclair, Peter J.,Wong, Frederick,Staruch, Mary Jo,Dumont, Francis J.,Cryan, John G.,Wiederrecht, Gregory J.,Wyvratt, Matthew J.,Parsons, William H.
, p. 2085 - 2088 (1999)
A tether length study of C32-O-phenalkyl ether derivatives of ascomycin was conducted wherein it was determined that a 2-carbon tether provides optimum in vitro immunosuppressive activity. Oxygen-bearing substituents along the 2-carbon tether can further increase the potency of this design.
