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C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: A tether length study

DOI: 10.1016/S0960-894X(99)00335-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2085 - 2088 (1999)

Update date:2022-08-04

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Authors:

Goulet, Mark T.Goulet, Mark T.

Sinclair, Peter J.Sinclair, Peter J.

Wong, FrederickWong, Frederick

Staruch, Mary JoStaruch, Mary Jo

Dumont, Francis J.Dumont, Francis J.

Cryan, John G.Cryan, John G.

Wiederrecht, Gregory J.Wiederrecht, Gregory J.

Wyvratt, Matthew J.Wyvratt, Matthew J.

Parsons, William H.Parsons, William H.

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Article abstract of DOI:10.1016/S0960-894X(99)00335-2

A tether length study of C32-O-phenalkyl ether derivatives of ascomycin was conducted wherein it was determined that a 2-carbon tether provides optimum in vitro immunosuppressive activity. Oxygen-bearing substituents along the 2-carbon tether can further increase the potency of this design.

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Full text of DOI:10.1016/S0960-894X(99)00335-2

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