Bioorganic and Medicinal Chemistry Letters p. 2085 - 2088 (1999)
Update date:2022-08-04
Topics:
Goulet, Mark T.
Sinclair, Peter J.
Wong, Frederick
Staruch, Mary Jo
Dumont, Francis J.
Cryan, John G.
Wiederrecht, Gregory J.
Wyvratt, Matthew J.
Parsons, William H.
A tether length study of C32-O-phenalkyl ether derivatives of ascomycin was conducted wherein it was determined that a 2-carbon tether provides optimum in vitro immunosuppressive activity. Oxygen-bearing substituents along the 2-carbon tether can further increase the potency of this design.
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