C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: A tether length study

DOI: 10.1016/S0960-894X(99)00335-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2085 - 2088 (1999)

Update date:2022-08-04

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Authors:

Goulet, Mark T.

Sinclair, Peter J.

Wong, Frederick

Staruch, Mary Jo

Dumont, Francis J.

Cryan, John G.

Wiederrecht, Gregory J.

Wyvratt, Matthew J.

Parsons, William H.

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Article abstract of DOI:10.1016/S0960-894X(99)00335-2

A tether length study of C32-O-phenalkyl ether derivatives of ascomycin was conducted wherein it was determined that a 2-carbon tether provides optimum in vitro immunosuppressive activity. Oxygen-bearing substituents along the 2-carbon tether can further increase the potency of this design.

Full text of DOI:10.1016/S0960-894X(99)00335-2

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